文献类型：期刊文献

英文题名：Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1-NRF2 Pathway

作者：Li, Yaling[1,3];Wang, Xijia[2,4];Li, Shuyue[2,4];Wang, Lei[2,4];Ding, Ningning[2,4];She, Yali[3];Li, Changtian[3]

第一作者：李亚玲

通信作者：She, YL[1];Li, CT[1]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Study Preve, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Basic Med Sch, Lanzhou 730000, Peoples R China;[4]940th Hosp Joint Logist Support Peoples Liberat Ar, Dept Pathol, Lanzhou 730050, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, 35 Dingxi Dong Lu, Lanzhou 730000, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2025

外文期刊名：AMERICAN JOURNAL OF CHINESE MEDICINE

收录：;Scopus(收录号：2-s2.0-85216955574);WOS:【SCI-EXPANDED(收录号:WOS:001408488600001)】；

基金：This work was supported by Gansu Province Education Technology Innovation Project (No. 2023A-078), Gansu Province Science and Technology Projects (No. 24JRRA1015), National Natural Science Foundation of China (Nos. 82260927 and 82405224), and Gansu Postdoctoral Fund (Yaling Li).

语种：英文

外文关键词：KEAP1-NRF2 Signaling Pathway; Oxidative Stress; Chronic Diseases; Natural Products; Traditional Chinese Medicine

摘要：Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1-transcription factor NF-E2 p45-related factor 2 (KEAP1-NRF2) pathway plays a crucial role in maintaining redox homeostasis and regulating a multitude of biological processes such as inflammation, protein homeostasis, and metabolic homeostasis. In this paper, we present the findings of recent studies on the KEAP1-NRF2 pathway, which have revealed that it is aberrantly regulated and induces oxidative stress injury in a variety of diseases such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases, respiratory diseases, digestive diseases, and cancer. Given this evidence, targeting KEAP1-NRF2 represents a highly promising avenue for developing therapeutic strategies for chronic diseases, and thus the development of appropriate therapeutic strategies based on the targeting of the NRF2 pathway has emerged as a significant area of research interest. This paper highlights an overview of current strategies to modulate KEAP1-NRF2, as well as recent advances in the use of natural compounds and traditional Chinese medicine, with a view to providing meaningful guidelines for drug discovery and development targeting KEAP1-NRF2. Additionally, it discusses the challenges associated with harnessing NRF2 as a therapeutic target.