文献类型：期刊文献

英文题名：Research progress on the effect of hippocampal FXR regulation of CREB-BDNF signaling pathway on depression; [基于海马 FXR 调控 CREB-BDNF 信号通路影响抑郁症的研究进展]

作者：He H.; Guo M.; Ran L.; Wang Y.

第一作者：He H.

机构：[1]Gansu University of Chinese Medicine, Acupuncture and Tuina School, Gansu, Lanzhou, 730000, China

第一机构：甘肃中医药大学

年份：2025

卷号：30

期号：2 February

起止页码：265

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：Scopus(收录号：2-s2.0-105007323986)

语种：英文

外文关键词：CREB-BDNF; depression; FXR; signaling pathway

摘要：Depression is a mental disorder characterized by mood disturbances that pose a significant threat to human mental and physical health. In recent years, the farnesoid X receptor (FXR) has been found to be expressed in brain regions such as the hippocampus and is closely related to the onset of depression. It can also affect the downstream target cAMP response element binding protein (CREB) - brain-derived neurotrophic factor (BDNF) signaling pathway, holding promise as a new target for the treatment of depression. This article analyzes how hippocampal FXR regulates the CREB-BDNF signaling pathway and summarizes the latest research progress related to the pathogenesis of depression, with the aim of providing precise targeted ideas for the drug development and clinical treatment of depression. ? 2025 Chinese Journal of Clinical Pharmacology and Therapeutics. All rights reserved.