文献类型：期刊文献

中文题名：2型糖尿病患者舒张末期室间隔厚度与尿白蛋白/肌酐比值相关性的研究

英文题名：The relationship between interventricular septal dimensions and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus

作者：王丽娟[1];刘胜男[1];马红梅[1];武振亚[1];李凡凡[1];李京娟[1];杨睿斐[2];刘媛媛[2];王金羊[2]

第一作者：王丽娟

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃省人民医院内分泌科

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：33

期号：8

起止页码：561

中文期刊名：中国糖尿病杂志

外文期刊名：Chinese Journal of Diabetes

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(81760147、81560143、82360163);甘肃省自然基金(21JR1RA013)。

语种：中文

中文关键词：糖尿病;2型;舒张末期室间隔厚度;尿白蛋白/肌酐比值

外文关键词：Diabetes mellitus,type 2;Interventricular septal dimensions;Urinary albumin/creatinine ratio

摘要：目的探讨T2DM患者舒张末期室间隔厚度(IVSd)与UACR的相关性。方法选取2021年3月至2023年4月于甘肃省人民医院内分泌科住院的T2DM患者757例,根据UACR分为≤30 mg/g的单纯T2DM组(n=388)、30~300 mg/g的微量蛋白尿组(Mic,n=260)和≥300 mg/g的大量蛋白尿组(Mac,n=109)。收集各组一般临床资料及生化指标,彩色多普勒超声心动图记录左室射血分数(LVEF)、左室短轴缩短率(LVFS)、IVSd、舒张末期左室后壁厚度(LVPWd)、左心房前后径(LAD)。Pearson相关分析IVSd、LVPWd与肾功能指标的相关性。Logistic回归分析T2DM患者合并蛋白尿的影响因素。受试者工作特征(ROC)曲线分析DM病程、IVSd对T2DM患者合并蛋白尿的预测价值。结果T2DM、Mic、Mac组DM病程、SBP、FIns、Hb A1c、血肌酐(Scr)、24 h尿总蛋白定量(24 hUTP)、UACR、UAER、IVSd、LVPWd依次升高(P<0.05),e GFR、LVEF依次降低(P<0.05)。Mic组年龄高于T2DM组(P<0.05)。Mac组DBP、FPG高于T2DM、Mic组(P<0.05)。Pearson相关分析显示,IVSd、LVPWd与24 hUTP、UACR、UAER、Scr呈正相关(P<0.05),与e GFR呈负相关(P<0.05)。Logistic回归分析显示,DM病程、IVSd是T2DM患者合并蛋白尿的影响因素。ROC曲线分析显示,IVSd的曲线下面积为0.620,敏感度为43.3%,特异度为76.8%。结论DM病程、IVSd是T2DM患者合并蛋白尿的影响因素,随着IVSd的增加,T2DM患者出现蛋白尿风险升高。
Objective To investigate the relationship between interventricular septal dimensions(IVSd)and urinary albumin/creatinine ratio(UACR)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 757 patients with T2DM hospitalized in the Department of Endocrinology of Gansu Provincial People's Hospital from March 2021 to April 2024 were enrolled in this study.All the patients were divided into T2DM patients without proteinuria(n=388),microproteinuria group(Mic,n=260)and macroproteinuria group(Mac,n=109)according to the UACR levels.General clinical data and biochemical indexes were collected from all the patients.Color Doppler echocardiography was used to record left ventricular ejection fraction(LVEF),left ventricular fraction shortening(LVFS),IVSd,left ventricular posterior wall dimensions(LVPWd),and left atrial diameter(LAD).Pearson correlation analysis was conducted to analyze the correlation between IVSd,LVPWd and related indicators of renal function.Logistic regression analysis was conducted to analyze the influencing factors for T2DM patients with proteinuria.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of the DM duration and IVSd in patients with T2DM and proteinuria.Results The DM duration,SBP,FIns,HbA1c,Scr,24 hUTP,UACR,UAER,IVSd,LVPWd were increased successively(P<0.05),while LVEF and eGFR were decreased successively(P<0.05)in T2DM,Mic,Mac group.Age was higher in Mic group than in T2DM group(P<0.05).DBP and FPG were higher in Mac group than in T2DM and Mic group(P<0.05).Pearson correlation analysis showed that IVSd and LVPWd were positively correlated with 24 hUTP,UACR,UAER and Scr(P<0.05),and negatively correlated with eGFR(P<0.05).Logistic regression analysis indicated that the DM duration and IVSd were significant influencing factors for proteinuria in patients with T2DM.ROC curve showed that the area under ROC curve of IVSd was 0.620,with sensitivity 43.3%and specificity 76.8%,respeictively.Conclusions The DM duration and IVSd are influencing factors for UACR in patients with T2DM.The risk of proteinuria in T2DM patients increases with rising IVSd.