文献类型：期刊文献

英文题名：Integrated Traditional Chinese and Western medicine for ulcerative colitis with diabetes A protocol for systematic review and meta-analysis

作者：Lan, Yu-Ze[1];Bai, Ya-Li[1];Zhu, Xiang-Dong[1]

第一作者：Lan, Yu-Ze

通信作者：Zhu, XD[1]

机构：[1]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Basic Med Coll, Lanzhou, Gansu, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2021

卷号：100

期号：4

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85100986193);WOS:【SCI-EXPANDED(收录号:WOS:000612833500099)】；

基金：This study supported by the National Natural Science Foundation of China (Name: Study on the Mechanism of Intestinal Mucosa Barrier Injury for the Treatment of Ulcerative Colitis by Shugan Jianpi Method Based on Regulation of Intestinal Flora on ERS/UPR Signaling pathway of Intestinal Epithelial Cells; Grant No. 8167150826).

语种：英文

外文关键词：diabetes; meta-analysis; traditional Chinese medicine; ulcerative colitis; Western medicine

摘要：Background: This study aimed to access the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with ulcerative colitis (UC) combined diabetes. Methods: This protocol adheres to the preferred reporting items for systematic reviews and meta-analysis protocol statement. We plan to search 8 electronic databases to identify qualifying studies published from database inception until December 1, 2020. The software of EndNote reference manager (X9) will be used to study selection. A pre-developed standardized data collection form will be used to extract from all eligible studies. For included studies, the quality will be assessed by Cochrane Risk of bias tool. The RevMan 5.3 software (Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) developed by the Cochrane Collaboration will be used for all statistical analysis. If possible, meta-analysis will be undertaken for each of the outcomes. For continuous variable data, we will used mean differences with 95% confidence intervals (CIs) as summary statistics. For dichotomous variable data, we will calculate Mantel-Haenszel odds ratio with 95% CIs as summary statistics from the numbers of events in control and intervention groups. We will consider a result to be statistically significant if P < .05. If outcomes cannot be meta-analyzed, we will performer a descriptive analysis. Results: This study will be performed to test the efficacy and safety of integrated Traditional Chinese and Western medicine treatment for patients with UC combined diabetes. Conclusion: The results of our study will be published in a peer-reviewed journals, and we will promotion results in domestic and foreign conferences. Registration number: INPLASY2020120087 Ethics and dissemination: As a systematic review and meta-analysis which based on previously published literature, ethical approval, and informed consent from patients are not required.