文献类型：期刊文献

中文题名：[2+2]环加成反应及其在天然药物合成中的应用研究进展

英文题名：Research advance of [2+2] cycloaddition reaction and its applicationin the synthesis of natural medicine

作者：田会宁[1];王蕊霞[1];智怡菱[1];段国建[1]

第一作者：田会宁

机构：[1]甘肃中医药大学药学院,甘肃兰州730101

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2022

卷号：39

期号：3

起止页码：83

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

基金：甘肃省科技厅项目(21JR1RA265);甘肃中医药大学研究生创新基金项目(2021CX43)。

语种：中文

中文关键词：[2+2]环加成;光催化;过渡金属催化;有机小分子催化;天然药物;综述

外文关键词：[2+2]cycloaddition;photocatalysis;transition metal catalysis;small organic molecules catalysis;natural medicine;summary

摘要：对光催化、过渡金属催化、有机小分子催化条件下的[2+2]环加成反应研究进展及其在天然药物合成中的应用进行简要概述。认为在3种催化方式中,光催化的[2+2]环加成反应发展时间最长、应用最广泛,但普遍存在光能量利用效率偏低、反应底物范围较窄、产物的手性控制方面欠缺等问题,所以需要开发更为高效的光敏剂或手性光催化剂;有关过渡金属催化方法,应开发更多的廉价过渡金属催化剂,并且扩大此方法的适用范围;有机小分子催化方法还需要重点解决催化剂用量偏大及催化剂的回收利用低等方面的不足。基于以上问题,希望能够开发出催化效果更好、适用范围更广的催化剂或催化方式。
This paper summarizes the research advance of[2+2]cycloaddition reaction under photocatalysis,transition metal catalysis and small organic molecule catalysis and its application in natural drug synthesis.It holds that among the 3 catalytic methods,photocatalytic[2+2]cycloaddition reaction has the longest development time and the most extensive application,but there are generally low light energy utilization efficiency,narrow scope of the reaction substrate,and lack of chiral control of products,so it is necessary to develop more efficient photosensitizer or chiral photocatalysts.As for the transition metal catalytic method,cheaper transition metal catalysts should be developed and the application scope of this method should be expanded. Small organic molecules catalysis also needs to focus on solving the deficiencies of rather large catalyst dosage and low catalyst recycling.Based on the above problems,it is hoped to develop catalysts or catalytic methods with better catalytic effect and wider application range.