文献类型：期刊文献

英文题名：Influence of gut microecology in the development of malignant tumors and its potential therapeutic application: A review

作者：Qian, Jin-Ping[1];Jiang, Bing[2];Lei, Xu-Dong[3];Tian, Le-Le[1];Zhou, Ying[1];Teng, Jing-Quan[1];Yue, Jia[1];Li, Jin-Juan[1];Zhang, Yan[1,4,5]

第一作者：Qian, Jin-Ping

通信作者：Zhang, Y[1]

机构：[1]Gansu Univ Tradit Chinese Med, Gansu Key Lab Tradit Chinese Med Excavat & Innovat, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Canc Hosp, Lanzhou, Gansu, Peoples R China;[4]Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Tradit Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：102

期号：27

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85164256048);WOS:【SCI-EXPANDED(收录号:WOS:001025647200019)】；

基金：This study was supported by the Open Foundation of Northwest Collaborative Innovation Center for Traditional Chinese Medicine Co-constructed by Gansu Province & amp;MOE of PRC (Grant no. xbzzy-2022-05) and the Lanzhou Science and Technology Plan Project (Grant no. 2022-3-40).

语种：英文

外文关键词：gut microbiota; malignant neoplasm; mechanism of carcinogenesis; metabolites; therapeutic strategy

摘要：A microbial ecosystem is a complex community of multiple bacterial interactions. The potential role of gut microbiota in human health has already attracted the attention of many researchers. Dysregulation of the gut microbial community has been suggested to be closely associated with the progression of various chronic diseases. Malignant neoplasms represent a major global health burden and are now the leading cause of death. The formation of tumors is often thought to be influenced by genetic and environmental factors. Recent research advances have indicated that multiple malignancies may also be attributed to the gut microbiota. In this review, we highlight the complex interactions between gut microbes and their metabolites, as well as the potential impact of gut microecology on the occurrence and development of tumors. In addition, potential strategies for targeted therapy of tumors using gut microecology are discussed. In the near future, intestinal microecology is likely to be used for early screening of tumors and subsequent clinical treatment.