文献类型：期刊文献

中文题名：基于功能性近红外光谱技术观察针刺对创伤后应激障碍大鼠脑部血氧浓度的影响

英文题名：Effect of acupuncture on blood oxygen concentration in brain of rats with post-traumatic stress disorder based on functional near-infrared spectroscopy

作者：Zhang, Yan-feng[1];Han, Ya-di[1];Zhao, Zhong-ting[1];Yan, Xing-ke[1]

第一作者：张彦峰

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2019

卷号：17

期号：1

起止页码：9

外文期刊名：JOURNAL OF ACUPUNCTURE AND TUINA SCIENCE

收录：Scopus(收录号：2-s2.0-85058997101);WOS:【ESCI(收录号:WOS:000459792600002)】；

基金：This work was supported by Regional Science Fund of National Natural Science Foundation of China (No. 81460744).

语种：中文

外文关键词：Acupuncture Therapy; Point; Baihui (GV 20); Point; Shenmen (HT 7); Point; Neiguan (PC 6); Point; Taichong (LR 3); Stress Disorders; Post-traumatic; Spectroscopy; Near-infrared; Rats

摘要：ObjectiveTo observe the effect of acupuncture on blood oxygen concentration in the brain of rats with post-traumatic stress disorder (PTSD) based on functional near-infrared spectroscopy (fNIRS), thus to reveal the mechanisms of acupuncture in intervening the brain function of PTSD rats.MethodsSixty Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group, a grasping group, a paroxetine group and an acupuncture group, with 12 rats in each group. Except the blank group, rats in the other groups all received incarceration plus electric shock for 7 d to prepare the PTSD animal model. One hour before the stress model was established, rats in each group received the designated intervention: rats in the blank group and the model group did not receive any intervention; rats in the grasping group received grasping and fixation; rats in the paroxetine group received paroxetine hydrochloride solution by intragastric administration; and rats in the acupuncture group received acupuncture. Six-day treatment was a course, with 2 courses of treatment conducted for a total of 12 d. After the modeling, rats in each treatment group received intervention for 5 d, and the fNIRS system was used to collect and record the changes in the concentrations of oxygenated hemoglobin (HbO(2)), deoxygenated hemoglobin (d-Hb) and total hemoglobin (t-Hb) of the involved rat's brain regions, and also to assess the brain function.ResultsCompared with the blank group, the concentration of HbO2 was significantly increased, the concentration of d-Hb was significantly decreased, and the concentration of t-Hb was significantly increased in the model group and the grasping group after the intervention, and the differences were statistically significant (all P<0.01). Compared with the model group, the concentrations of HbO(2), d-Hb and t-Hb in the grasping group did not change significantly (all P>0.05). Compared with the grasping group, the concentration of HbO(2) was significantly decreased, the concentration of d-Hb was significantly increased, and the concentration of t-Hb was significantly decreased in the paroxetine group and the acupuncture group, and the differences were statistically significant (all P<0.05). There were no significant differences in the concentrations of HbO(2), d-Hb and t-Hb between the paroxetine group and the acupuncture group (all P>0.05).ConclusionAcupuncture can regulate the blood oxygen concentration in the brain of PTSD model rats, which may be an important mechanism of acupuncture in intervening the brain function in PTSD rats.