文献类型：期刊文献

中文题名：自身免疫性肝炎的性别二型性:现有证据与治疗挑战

英文题名：Gender dimorphism in autoimmune hepatitis:current evidence and future challenges

作者：张照杰[1,2];朱惠娟[1,2];李向向[1,2];王振[1,2];杨妹霞[1,2];张婷[1,2];郭会姬[1,2];郑晓凤[3];于晓辉[1];张久聪[1]

第一作者：张照杰

机构：[1]中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730000;[2]甘肃中医药大学第一临床医学院;[3]兰州大学第二医院消化内科

第一机构：中国人民解放军联勤保障部队第九四〇医院消化内科,甘肃兰州730000

年份：2026

卷号：35

期号：5

起止页码：628

中文期刊名：胃肠病学和肝病学杂志

外文期刊名：Chinese Journal of Gastroenterology and Hepatology

基金：甘肃省卫生健康行业科研计划项目(GSWSKY2023-34);兰州市青年科技人才创新项目(2024-QN-39);兰州市科技计划项目(2024-9-155、2024-9-158、2023-ZD-181)。

语种：中文

中文关键词：自身免疫性肝炎;性别二型性;性别差异;机制

外文关键词：Autoimmune hepatitis;Gender dimorphism;Gender differences;Mechanisms

摘要：自身免疫性肝炎(autoimmune hepatitis,AIH)是一种病因尚未完全阐明的慢性炎症性疾病,女性的发病率、症状及预后往往比男性更严重,男女发病差异导致AIH显著的异质性,而目前关于AIH男女发病差异的原因及相关治疗尚无文献系统汇总。本文结合近几年AIH发病相关病因及治疗的研究文献,总结出男女性AIH发病差异悬殊的原因主要受遗传、雌激素、免疫及环境等几方面影响,并总结目前针对性别差异的治疗,以期为AIH性别二型性研究提供进一步方向,从而提供更为精准的治疗策略。
Autoimmune hepatitis(AIH)is a chronic inflammatory disease whose etiology has not yet been fully elucidated,and the incidence,symptoms and prognosis of AIH in women tend to be more severe than those in men.The difference in the incidence between men and women has led to the significant heterogeneity of AIH,and there is no systematic summary of the literature on the causes of the difference between men and women in the incidence of AIH and the related treatment.In this paper,we summarized the causes of the differences in the incidence of AIH between men and women,which are mainly affected by genetics,estrogen,immunity and the environment,and summarized the current treatments for gender differences,with a view to providing further direction for the study of gender dimorphism in AIH,so as to provide a more accurate therapeutic strategy.