文献类型：期刊文献

英文题名：Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistance

作者：Chen, Yawen[1,2];Yang, Jian[1,2];Du, Yadan[1,2];Yan, Zaihua[3];Gao, Jieyun[1,2];Zhang, Haoyang[2,4];Wu, Qiong[2,4];Nian, Bowen[5];Huang, Xiujuan[6,7];Da, Mingxu[1,2,4]

第一作者：Chen, Yawen;陈彦文

通信作者：Da, M[1];Da, M[2];Da, M[3]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Dept Surg Oncol, Lanzhou 730000, Peoples R China;[3]North Sichuan Med Coll, Affiliated Hosp, Dept Gastrointestinal Surg 2, Nanchong 637000, Peoples R China;[4]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[5]First Peoples Hosp Huating, Dept Gen Surg, Huating 744100, Peoples R China;[6]Gansu Prov Hosp, Dept Hematol, Lanzhou 730000, Peoples R China;[7]Shanxi Prov Peoples Hosp, Dept Thorac Surg, Xian 710068, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Surg Oncol, Lanzhou 730000, Peoples R China;[3]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

期号：1

外文期刊名：DISCOVER ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85218439879);WOS:【SCI-EXPANDED(收录号:WOS:001423906000001)】；

基金：Not applicable.

语种：英文

外文关键词：NAT10; Gastric cancer; EMT; Proliferation; Invasion; Migration; Chemotherapy; Wnt/beta-catenin pathway

摘要：BackgroundN-acetyltransferase 10 (NAT10) is involved in several cellular processes. NAT10 expression is essential for the promotion of mRNA translation and stability. In some situations, deregulation of NAT10 has been attributed to the development of multiple types of cancer. NAT10 is significantly upregulated in various gastrointestinal tumors, including esophageal, colorectal, pancreatic, and liver cancers, and is correlated with poor prognosis. Additionally, NAT10 expression contributes to chemotherapy resistance in both esophageal and colorectal cancers. Nevertheless, the role of NAT10 in gastric cancer (GC), a type of gastrointestinal tumor, is not fully understood.MethodsThroughout this investigation, our team evaluated NAT10 expression levels in GC patient samples and databases available to the general public. Based on the knockdown and overexpression of NAT10, in vitro experiments were conducted to examine the effects of NAT10 on GC progression and resistance to chemotherapy.ResultsOur study demonstrated that GC tissues exhibit increased levels of NAT10. Downregulation of NAT10 decreased GC cell proliferation, migration, and invasiveness. Conversely, upregulation of NAT10 resulted in the opposite effect. Furthermore, NAT10 fosters the progression of GC cells by activating the Wnt/beta-catenin signaling pathway. NAT10 also promotes resistance to cisplatin chemotherapy.ConclusionsOur findings indicated that expression of NAT10 promoted GC progression through activation of the Wnt/beta-catenin signaling pathway. We investigated the effect of NAT10 on the viability of GC cells treated with different doses of cisplatin. The results showed that NAT10 expression could impact the effectiveness of chemotherapy resistance in GC. This implies that using NAT10 as a target may be a potential therapeutic strategy for treating GC.