文献类型：期刊文献

英文题名：Spinal Cord Injury: A Systematic Review and Network Meta-Analysis of Therapeutic Strategies Based on 15 Types of Stem Cells in Animal Models

作者：Shang, Zhizhong[1];Wang, Ruirui[1];Li, Dongliang[1];Chen, Jinlei[1];Zhang, Baolin[1];Wang, Mingchuan[1];Wang, Xin[1,2,3];Wanyan, Pingping[4,5]

第一作者：Shang, Zhizhong

通信作者：Wang, X[1];Wang, X[2];Wang, X[3];Wanyan, PP[4];Wanyan, PP[5]

机构：[1]Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China;[2]Chengren Inst Tradit Chinese Med, Lanzhou, Peoples R China;[3]Naval Med Univ, Changzheng Hosp, Dept Spine, Shanghai, Peoples R China;[4]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[5]Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China;[2]corresponding author), Chengren Inst Tradit Chinese Med, Lanzhou, Peoples R China;[3]corresponding author), Naval Med Univ, Changzheng Hosp, Dept Spine, Shanghai, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China;[5]corresponding author), Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85127549013);WOS:【SCI-EXPANDED(收录号:WOS:000783484900001)】；

基金：Funding We acknowledge the financial support from Gansu Natural Science Foundation (No. 21JR7RA362; 21JR7RA413) and The First Hospital of Lanzhou University Foundation (No. ldyyyn2021-121).

语种：英文

外文关键词：stem cell; spinal cord injury; therapeutic strategies; animal studies; systematic review; network meta-analysis

摘要：Objective: The optimal therapeutic strategies of stem cells for spinal cord injury (SCI) are fully explored in animal studies to promote the translation of preclinical findings to clinical practice, also to provide guidance for future animal experiments and clinical studies.& nbsp;Methods: PubMed, Web of Science, Embase, CNKI, Wangfang, VIP, and CBM were searched from inception to September 2021. Screening of search results, data extraction, and references quality evaluation were undertaken independently by two reviewers.& nbsp;Results and Discussion: A total of 188 studies were included for data analysis. Results of traditional meta-analysis showed that all 15 diverse types of stem cells could significantly improve locomotor function of animals with SCI, and results of further network meta-analysis showed that adipose-derived mesenchymal stem cells had the greatest therapeutic potential for SCI. Moreover, a higher dose (>= 1 x 106) of stem cell transplantation had better therapeutic effect, transplantation in the subacute phase (3-14 days, excluding 3 days) was the optimal timing, and intralesional transplantation was the optimal route. However, the evidence of current animal studies is of limited quality, and more high-quality research is needed to further explore the optimal therapeutic strategies of stem cells, while the design and implementation of experiments, as well as measurement and reporting of results for animal studies, need to be further improved and standardized to reduce the risk when the results of animal studies are translated to the clinic.