文献类型：期刊文献

英文题名：Protein Post-Translational Modifications in the Regulation of Ferroptosis: New Opportunities and Challenges for Cancer Immunotherapy

作者：Xie, Xin[1,2,3];Song, Lizhou[1,2];Li, Zhaoyu[4];Hu, Jiahao[1,2,3];Lin, Zhiheng[5];Guo, Yadong[6];Zhang, Haoling[7];Zhang, Wangzheqi[1,2];Zou, Zui[1,2]

第一作者：Xie, Xin

通信作者：Zhang, WZQ[1];Zou, Z[1];Zhang, WZQ[2];Zou, Z[2];Zhang, HL[3]

机构：[1]Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai 200433, Peoples R China;[2]Naval Med Univ, Sch Anesthesiol, 168 Changhai Rd, Shanghai 200433, Peoples R China;[3]Naval Med Univ, Coll Basic Med Sci, Shanghai 200433, Peoples R China;[4]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[5]Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Gynecol, Shanghai 200032, Peoples R China;[6]Tongji Univ, Shanghai Peoples Hosp 10, Dept Urol, 301 Yanchang Rd, Shanghai 200040, Peoples R China;[7]Univ Sains Malaysia, Dept Biomed Sci, Pusat Kanser Tun Abdullah Ahmad Badawi, Kepala Batas 13200, Pulau Pinang, Malaysia

第一机构：Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai 200433, Peoples R China

通信机构：[1]corresponding author), Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai 200433, Peoples R China;[2]corresponding author), Naval Med Univ, Sch Anesthesiol, 168 Changhai Rd, Shanghai 200433, Peoples R China;[3]corresponding author), Univ Sains Malaysia, Dept Biomed Sci, Pusat Kanser Tun Abdullah Ahmad Badawi, Kepala Batas 13200, Pulau Pinang, Malaysia.

年份：2026

卷号：22

期号：14

起止页码：7963

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

收录：;Scopus(收录号：2-s2.0-105049492090);WOS:【SCI-EXPANDED(收录号:WOS:001870305900005)】；

基金：This study was funded by The National Natural Science Foundation of China (Grant No. 82572494) .

语种：英文

外文关键词：ferroptosis; protein post-translational modification; cancer immunotherapy; immune escape; lipid metabolism; combined therapy

摘要：Ferroptosis is an emerging form of programmed cell death driven by the excessive accumulation of iron-dependent lipid peroxides, which plays a pivotal regulatory role in suppressing tumor initiation and progression. In recent years, protein post-translational modification (PTM), as a core molecular mechanism regulating protein function, stability, and subcellular localization, occupies a central position in the precise targeted regulation of ferroptosis. This review systematically summarizes and elucidates the core molecular regulatory mechanisms of ferroptosis, focusing on the dynamic regulatory pathways and effects of common protein PTM (including ubiquitination, phosphorylation, acetylation and lactylation) on key ferroptosis regulators. Meanwhile, it deeply analyzes the complex interactive regulatory network between ferroptosis and tumor immunity, and elaborates on the specific pathways by which ferroptosis remodels the tumor immune microenvironment through inducing immunogenic cell death (ICD) and releasing damage-associated molecular patterns (DAMPs). More importantly, this paper systematically discusses the potential application value of ferroptosis-related protein PTM in overcoming tumor immune escape, enhancing the antitumor activity of T cells and natural killer cells, and improving the clinical efficacy of immune checkpoint inhibitors (ICIs). Finally, it summarizes the core challenges existing in this research field and prospects the future development of novel PTM-based combination antitumor strategies targeting ferroptosis and personalized antitumor therapy. This review aims to provide new theoretical references and experimental evidence for the clinical prevention, treatment and intervention of malignant tumors.