文献类型：期刊文献

英文题名：Hybrid immunity strategies: heterologous vaccination combined with natural SARS-CoV-2 infection

作者：Huang, Yuan[1];Zhang, Xiaolu[1];Miao, Ruixia[1];Wang, Jing[1];Xi, Xuan[1];Pan, Heng[1];Lu, Yan[2];Li, Dehong[3]

第一作者：黄勇

通信作者：Lu, Y[1];Li, DH[2]

机构：[1]Gansu Univ Chinese Med, Dept Publ Hlth, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Dept Blood Transfus, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Blood Transfus, Lanzhou, Peoples R China.

年份：2026

卷号：13

外文期刊名：FRONTIERS IN MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001755578500001)】；

语种：英文

外文关键词：antigenic distance; heterologous strategies; hybrid immunity; immune memory; SARS-CoV-2 variants

摘要：The continuous evolution of SARS-CoV-2 poses a significant challenge to existing immune barriers, highlighting the limitations of single-modality immunization. Hybrid immunity, shaped by the combination of natural infection and vaccination, induces more potent, broad-spectrum, and durable protective immunity. This review proposes that heterologous vaccination - the sequential use of vaccines based on different technological platforms - can serve as an active public health strategy to simulate and optimize hybrid immunity. We systematically elaborate on the synergistic advantages of hybrid immunity at both the humoral and cellular levels, citing evidence from multiple clinical trials that for both convalescent individuals and infection-na & iuml;ve populations, heterologous vaccination regimens outperform homologous regimens in enhancing the breadth of neutralizing antibodies, strengthening cross-protection, and establishing robust immune memory. By mimicking the antigenic distance effect, heterologous vaccination safely replicates the immunological benefits of natural infection without the associated risks, positioning it as a key strategic tool to counter persistent viral evolution and build a resilient population-wide immune barrier.