文献类型：期刊文献

中文题名：基于Citespace分析中医药治疗骨质疏松症的研究热点和趋势

英文题名：An Analysis of Research Hotspots and Trends of TCM in the Treatment of Osteoporosis Based on Citespace

作者：陈海亮[1];赵瑞[1];裴雪冬[1];宁浩驰[1];潘静[1];张浩令[2];蒋宇航[1];王薇[1];宋志靖[1]

第一作者：陈海亮

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]圣彼得堡国立大学,俄罗斯圣彼得堡190000

第一机构：甘肃中医药大学

年份：2022

卷号：42

期号：9

起止页码：1376

中文期刊名：河南中医

外文期刊名：Henan Traditional Chinese Medicine

基金：国家自然科学基金项目(81960877);甘肃省自然科学基金项目(21JR7RA561);甘肃省高等学校创新基金项目(2021A-076)。

语种：中文

中文关键词：骨质疏松症;中医药;Citespace分析

外文关键词：osteoporosis;TCM;Citespace analysis

摘要：目的:基于Citespace对中医药治疗骨质疏松症(osteoporosis,OP)的中文文献进行研究现状、研究热点及前沿展示与分析。方法:检索中国知网、万方数据知识服务平台、维普中文期刊服务平台等数据库2000-2021年发表的中医药治疗OP的相关文献,统计发文量、文章发表年度及发表期刊;使用Citespace 5.8.R2软件对文献共现网络和关键词进行可视化分析。结果:共纳入文献6613篇,2000-2021年发文量总体呈增长趋势,共有585本期刊收录了中医药治疗OP的相关文章,中国骨质疏松杂志发文量为875篇。发文量最高的作者为郑洪新(82篇),高产作者之间存在合作关系,形成了以郑洪新团队为代表的核心团队,中介中心性>0的作者共23位。涉及589个科研机构,形成了以中医院校为代表的研究机构,中介中心性>0的机构55个。关键词共现分析发现有骨质疏松、老年、中医药、补肾药、骨钙素等192个关键词,对其聚类分析发现骨质疏松、成骨细胞、动物、中医中药、药理作用等13个关键词聚类标签;关键词突现分析发现25个突现词,实验研究、动物等是突现时间较早的关键词,信号通路、中医药等是突现时间较迟关键词,中医中药、骨代谢等为突现强度较大的关键词。关键词时间线图谱分析将关键词分为三部分。结论:中医药治疗OP的作用机制具有多靶点、多通路、整体调节的优势。但目前存在单味中药研究处于实验阶段、中药复方成分复杂、疗效不确定等不足之处,今后应借助网络药理学等科研方法明确其作用机制,充分发掘有效成分。
Objective:To display and analyze the research status,research hotspots and frontier of Chinese literature on the treat-ment of osteoporosis(OP)with TCM based on Citespace.Methods:The relevant literature on the treatment of OP with TCM pub-lished in databases such as CNKI,Wanfang Data knowledge service platform and VIP Chinese journal service platform from 2000 to 2021 were retrieved,and the number of articles published,the year of publication and the periodicals published were counted.The literature co-occurrence network and keywords were visually analyzed by using Citespace 5.8 R2 software.Results:A total of 6613 articles were included,and the number of articles published from 2000 to 2021 showed an overall growth trend.A total of 585 journals included articles related to the treatment of OP with TCM,and the number of articles published in the Chinese Journal ofOsteoporosis was 875.The author with the highest number of publications was Zheng Hong-xin(82),and there was a cooperative relationship between high-yield authors,forming a core team represented by Zheng Hong-xin′s team.There were 23 authors with in-termediary centrality more than zero.Involving 589 scientific research institutions,a research institution represented by TCM colle-ges and universities was formed,and there were 55 institutions with intermediary centrality more than zero.The keyword co-occur-rence analysis found 192 keywords such as osteoporosis,old age,TCM,kidney-tonifying drugs,osteocalcin,etc.,and the cluster a-nalysis found 13 keyword cluster labels such as osteoporosis,osteoblasts,animals,TCM,pharmacological effects,etc.The keyword emergence analysis found that 25 emergent words,and among of them,experimental research,animals,etc.were the keywords with earlier emergence time,while signal pathway,TCM,etc.were the keywords with later emergence time,and TCM,bone metabolism,etc.were the words with greater emergence intensity.Keyword timeline analysis divided keywords into three parts.Conclusion:The research on the action mechanism of TCM in the treatment of OP,which has the advantages of multi-target,multi-channel and over-all regulation.However,at present,the research of single Chinese medicinal is in the experimental stage,the components of Chi-nese medicinals are complex,and the curative effect is uncertain.In the future,we should use scientific research methods such as network pharmacology to clarify its mechanism of action and fully explore the effective components.