文献类型：期刊文献

中文题名：基于“脑为髓海”理论探讨脑部相关疾患与骨质疏松症的相关性

英文题名：Discussion on Correlation of Brain Diseases and Osteoporosis Based on Theory of “Brain Being The Sea of Marrow”

作者：赵继荣[1];史凡凡[1];马同[2];朱换平[2];陈文[2];赵宁[2];薛旭[2];杨涛[1];张立存[1];李玮农[1];蒋鹏[1];杨文通[1]

第一作者：赵继荣

机构：[1]甘肃中医药大学,甘肃兰州730030;[2]甘肃省中医院,甘肃兰州730050

第一机构：甘肃中医药大学

年份：2022

卷号：40

期号：10

起止页码：12

中文期刊名：中华中医药学刊

外文期刊名：Chinese Archives of Traditional Chinese Medicine

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：国家自然科学基金(81760877);甘肃省自然科学基金(21JR1RA050);甘肃省青年科技基金计划(21JR1RA057);甘肃省科技计划(20YF3FA016);甘肃省科技计划重大项目(21ZD4FA009)。

语种：中文

中文关键词：“脑为髓海”;脑部疾患;骨质疏松症;相关性机制

外文关键词：brain being the sea of marrow;brain disorders;osteoporosis;correlation mechanism

摘要：人口老龄化的到来是现在脑部相关疾患及骨质疏松症(osteoporosis, OP)发病率居高不下的重要因素之一。近年来研究表明,OP的发病往往与脑部相关疾患同步发生,如帕金森病(Parkinson’s disease, PD)患者与OP患者具有一定重叠性。脑部病变可直接或间接导致患者活动减少乃至长期卧床失去肌肉对骨骼机械应力刺激而导致骨量丢失,最终导致OP的发生发展。现代中医药学往往将OP的防治重点置于肾、肝、脾等脏腑,而忽视了“脑”的作用,但人体是一个有机整体,脑作为人体神经系统的核心中枢,通过神经肽等信号物质直接或间接影响人体骨的形成与代谢。故脑与骨两系统在生理上互惠互利,脑部疾患与OP在病理上互为因果。中医学认为脑为髓海,主宰人体的生命活动,髓海充盈以濡养四肢百骸;髓海空虚则筋骨失养而发为骨痿。因此以中医“脑为髓海”理论出发,结合现代医学研究成果,探讨脑部相关疾患与OP相关性,为OP防治提供理论新思路。
The arrival of the aging population is one of the important factors for the current high incidence of brain-related diseases and osteoporosis(OP). Recent studies have shown that the onset of OP often occurs simultaneously with brain-related diseases. For example, Parkinson’s disease(PD) patients and OP patients have a certain overlap. Brain lesions can directly or indirectly lead to reduced activity and even long-term bed rest loss of muscles and mechanical stress stimulation of bones, leading to bone loss, and ultimately leading to the occurrence and development of OP. Modern traditional Chinese medicine often focuses on the prevention and treatment of OP in the kidney, liver, spleen and other organs, while ignoring the role of the “brain”. However, the human body is an organic whole. The brain is the core center of the human nervous system through neuropeptides and other signal substances directly or indirectly affect the formation and metabolism of human bone. Therefore, the two systems of brain and bone are mutually beneficial in physiology, and brain diseases and OP are mutually cause and effect in pathology. Traditional Chinese medicine believes that the brain is a sea of marrow, which dominates the life activities of the human body. The sea of marrow is filled to nourish the limbs. If the sea of marrow is empty, the bones and muscles become dystrophic and cause osteopenia. Therefore, this article is based on the theory of “brain as the sea of marrow” in traditional Chinese medicine, combined with modern medical research results, to explore the correlation between brain-related diseases and OP,and provide new theoretical ideas for the prevention and treatment of OP.