文献类型：期刊文献

英文题名：Review: Mechanisms and perspective treatment of radioresistance in non-small cell lung cancer

作者：Zhou, Ting[1,2,3];Zhang, Li-Ying[1,2,4];He, Jian-Zheng[1,2,4];Miao, Zhi-Ming[1,2];Li, Yang-Yang[1,2];Zhang, Yi-Ming[1,2];Liu, Zhi-Wei[1,2];Zhang, Shang-Zu[1,2];Chen, Yan[1,2];Zhou, Gu-Cheng[1,2];Liu, Yong-Qi[1,2,4,5]

第一作者：周婷

通信作者：Liu, YQ[1];Liu, YQ[2];Liu, YQ[3];Liu, YQ[4]

机构：[1]Gansu Univ Chinese Med, Provincial Level Key Laboratory for Molecular Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Expt & Training Teaching Ctr, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Minist, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Provincial Level Key Laboratory for Molecular Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Minist, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85149269928);WOS:【SCI-EXPANDED(收录号:WOS:000940224000001)】；

基金：This work was supported by the National Natural Science Foundation of China (No.81973595), The basic research Innovation Group in Gansu (No.20JR10RA332), Provincial University industry support project in Gansu (No. 2020C-15), and National Natural Science Foundation of China (No.82260882).

语种：英文

外文关键词：non-small cell lung cancer; radiotherapy; radioresistance mechanisms; toxicity; Traditional Chinese Medicine

摘要：Radiotherapy is the major treatment of non-small cell lung cancer (NSCLC). The radioresistance and toxicity are the main obstacles that leading to therapeutic failure and poor prognosis. Oncogenic mutation, cancer stem cells (CSCs), tumor hypoxia, DNA damage repair, epithelial-mesenchymal transition (EMT), and tumor microenvironment (TME) may dominate the occurrence of radioresistance at different stages of radiotherapy. Chemotherapy drugs, targeted drugs, and immune checkpoint inhibitors are combined with radiotherapy to treat NSCLC to improve the efficacy. This article reviews the potential mechanism of radioresistance in NSCLC, and discusses the current drug research to overcome radioresistance and the advantages of Traditional Chinese medicine (TCM) in improving the efficacy and reducing the toxicity of radiotherapy.