文献类型：期刊文献

中文题名：丙氨酰-谷氨酰胺在急性重症胰腺炎急诊治疗中的应用效果观察

英文题名：Observation on the Effect of Alanyl-Glutamine in Emergency Treatment of Severe Acute Pancreatitis

作者：谢海[1];畅艳娜[2]

第一作者：谢海

机构：[1]兰州大学第一医院急诊科,甘肃兰州730000;[2]甘肃中医药大学附属医院麻醉科,甘肃兰州730000

第一机构：兰州大学第一医院急诊科,甘肃兰州730000

年份：2020

卷号：11

期号：14

起止页码：108

中文期刊名：中国卫生标准管理

外文期刊名：China Health Standard Management

语种：中文

中文关键词：丙氨酰-谷氨酰胺;急性重症胰腺炎;急诊;应用效果;APACHEⅡ;Ranson

外文关键词：alanyl-glutamine;acute severe pancreatitis;emergency;application effect;APACHEⅡ;Ranson

摘要：目的观测丙氨酰-谷氨酰胺(alanyl-glutamine,ala-gln)治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的疗效。方法对我院120例SAP患者的临床资料进行回顾性分析,按随机表法划分成观察组与对照组各60例。对照组给予一般常规治疗和静滴生长抑素,观察组在此基础上给予静滴ala-gln,治疗10天后,观察症状缓解时间、APACHEⅡ和Ranson评分以及各项实验室指标的变化,对临床疗效进行评估。结果观察组腹痛缓解时间、腹胀缓解时间、发热消退时间、肠功能恢复时间均较对照组提前(P<0.01);APACHEⅡ和Ranson评分较对照组降低明显(P<0.01);治疗后观察组实验室相关指标均较对照组有更加明显的改善(P<0.01);观察组临床疗效优于对照组(P<0.05)。结论ala-gln治疗SAP可减轻临床症状,促使炎症消退,改善肠功能和肝功能,临床疗效显著。
Objective To observe the efficacy of alanyl-glutamine(alagln)in the treatment of severe acute pancreatitis(SAP).Methods The clinical data of 120 patients with SAP in our hospital were analyzed retrospectively.The patients were randomly divided into observation group(n=60)and control group(n=60).The control group was given routine treatment and intravenous infusion of somatostatin,while the observation group was treated with intravenous ala-gln,for 10 days.The symptom relief time,Apache Ⅱ and Ranson scores and the changes of laboratory indexes were observed,and the clinical efficacy was evaluated.Results The relief time of abdominal pain,abdominal distension,fever and intestinal function in the observation group were earlier than those in the control group(P<0.01),and the scores of APACHE Ⅱ and Ranson in the observation group were significantly lower than those in the control group(P<0.01).After treatment,the laboratory related indexes in the observation group were significantly better than those in the control group(P<0.01),and the clinical effect of the observation group was better than that of the control group(P<0.05).Conclusion ala-gln treatment of SAP can relieve clinical symptoms,promote the disappearance of inflammation,improve intestinal function and liver function,and the clinical effect is significant.