文献类型：期刊文献

英文题名：Analysis of the current status and associated risk factors of cognitive function in Tibetan hypertensive patients at various altitudes

作者：Yin, Long[1,2];Zhang, Xiaoming[2,3];Zhang, Huijuan[2,3];Li, Ruizhen[2,3];Zeng, Jing[2,4];Dong, Kaixuan[1];Wang, Yi[1,2];Li, Xinghui[1,2]

第一作者：Yin, Long

通信作者：Li, XH[1]

机构：[1]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Cardiol, 204 Donggang West Rd, Lanzhou 73000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[4]Ningxia Med Univ, Yinchuan, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Cardiol, 204 Donggang West Rd, Lanzhou 73000, Gansu, Peoples R China.

年份：2024

卷号：46

期号：1

外文期刊名：CLINICAL AND EXPERIMENTAL HYPERTENSION

收录：;Scopus(收录号：2-s2.0-85202474196);WOS:【SCI-EXPANDED(收录号:WOS:001300452200001)】；

基金：The funding project for this study is "Gansu Province Health Industry Research Program". Project number: GSWSKY-2021-020.

语种：英文

外文关键词：Altitudes; Tibetans; hypertension; cognitive dysfunction; MMSE

摘要：Objective This study aims to explore the current cognitive status and identify risk factors associated with cognitive function in Tibetan hypertensive patients living at various altitudes. Methods The Simple Mental Status Scale (MMSE) was used to evaluate the cognitive function of 611 Tibetan hypertensive patients at various altitudes in Gannan Tibetan Autonomous Prefecture. Afterward, we conducted an analysis to identify the factors influencing their cognitive function. Results The study found that the prevalence of cognitive dysfunction was 22.3%, with a higher incidence at high altitude (group D 29.0%) compared to low altitude (group A 16.0%). The study conducted a binary logistic regression analysis to identify the risk factors for cognitive dysfunction. The analysis revealed that altitude, age, body mass index, marital status, education, income level, and blood pressure control level were all significant risk factors. After controlling for age, body mass index, marital status, educational level, income level, and blood pressure control level, the risk of developing cognitive dysfunction was 2.773 times higher (p < .05) for individuals in group C at high altitude and 2.381 times higher (p < .05) for individuals in group D at high altitude compared to those in group A at low altitude. Conclusions Altitude plays a role in the development of cognitive dysfunction in hypertensive patients. Tibetan hypertensive patients living at high altitudes may be at a higher risk of cognitive dysfunction compared to those living at lower altitudes. Therefore, interventions should be targeted to prevent or mitigate potential cognitive impairment.