文献类型：期刊文献

英文题名：Gut microbiota-derived metabolites in cardiovascular disease: Focus on trimethylamine N-oxide, short-chain fatty acids and bile acids (Review)

作者：Gao, Meizhu[1];Hao, Zhenming[2];Li, Yiling[1];Liu, Weixue[1];Zhang, Fubao[1]

第一作者：Gao, Meizhu

通信作者：Liu, WX[1];Zhang, FB[1]

机构：[1]Gansu Univ Tradit Chinese Med, Baiyin Peoples Hosp 1, Affiliated Hosp 3, Dept Cardiovasc Med, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Baiyin Peoples Hosp 1, Affiliated Hosp 3, Dept Urol, Baiyin 730900, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Baiyin Peoples Hosp 1, Affiliated Hosp 3, Dept Cardiovasc Med, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：34

期号：2

外文期刊名：MOLECULAR MEDICINE REPORTS

收录：;Scopus(收录号：2-s2.0-105042210939);WOS:【SCI-EXPANDED(收录号:WOS:001795666900001)】；

基金：Not applicable.

语种：英文

外文关键词：gut microbiota; gut-heart axis; trimethylamine n-oxide; short-chain fatty acids; bile acids; atherosclerosis; hypertension; heart failure

摘要：The gut-heart axis, where microbial metabolites act as key signaling molecules, represents a notable frontier in cardiovascular medicine. An expanding body of evidence has demonstrated that gut microbiota-derived metabolites, particularly trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs) and bile acids (BAs), play divergent roles in the pathogenesis of cardiovascular diseases. While elevated TMAO levels are consistently linked to pro-atherogenic and pro-thrombotic outcomes, SCFAs generally confer vasoprotective and anti-inflammatory benefits. BAs exhibit dual functions, regulating both lipid metabolism and inflammatory signaling through dedicated receptors. The dynamic balance among these metabolites, which is markedly influenced by diet and microbial composition, collectively shapes cardiovascular risk. The present review critically synthesized the current mechanistic evidence on how TMAO, SCFAs and BAs contribute to hypertension, atherosclerosis and heart failure, with the aim to provide a cohesive framework for the development of novel diagnostic and therapeutic strategies.