文献类型：期刊文献

中文题名：长链非编码RNA AFAP1-AS1在癌症中作用及其机制的研究进展

英文题名：Research progress on the mechanism of long chain non-coding RNA AFAP1-AS1 in cancer

作者：李志明[1];龙凤[1,2];何建新[1];黄勇[1,2];孙少康[1]

第一作者：李志明

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省高校重大疾病分子医学与中医药防治研究省级重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：31

期号：4

起止页码：350

中文期刊名：中国癌症杂志

外文期刊名：China Oncology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

语种：中文

中文关键词：LncRNA;AFAP1-AS1;癌症;机制

外文关键词：LncRNA;AFAP1-AS1;Cancer;Mechanism

摘要：癌症一直是全球非感染性疾病死亡的主要原因之一,癌症的有效筛查和早期诊断、早期治疗一直以来是临床的一大难点,鉴定新的生物标志物或分子靶标以改善癌症患者的诊断和治疗刻不容缓。近年来研究发现,长链非编码RNA(long non-coding RNA,lncRNA)是一系列生物行为和包括肿瘤在内的疾病发生、发展的主要调节因子,有望成为肿瘤检测和治疗的新的生物标志物和分子靶点。肌动蛋白丝相关蛋白1-反义RNA1(actin filament-associated protein1 antisense RNA1,AFAP1-AS1)最初在食管腺癌中被鉴定为致癌的lncRNA,后来被发现是多种恶性肿瘤的致癌调节剂。AFAP1-AS1的异常过表达可通过不同的分子机制来调控肿瘤细胞的增殖、凋亡、侵袭和转移等。AFAP-AS1在肿瘤组织中的表达上调具有重要的临床意义,解读该lncRNA在癌症中的功能和作用机制可以进一步帮助临床工作中寻找预防或治疗恶性肿瘤的新策略。为此,综述AFAP1-AS1在多种人类恶性肿瘤中的作用、相关分子机制和潜在的临床意义,为其早日应用于临床提供科学理论依据。
Cancer is one of the leading causes of death from non-infectious diseases in the whole world.Moreover,effective screening and early diagnosis and treatment of cancers have always been a major clinical difficulty.Therefore,it is urgent that novel potential biomarkers or molecular targets are identified to improve the diagnosis and treatment of cancer patients.In recent years,it has been found that long non-coding RNAs(lncRNAs)are a series of main regulatory factors in biological behaviors and diseases including tumors,and are expected to become novel biomarkers and molecular targets for tumor detection and treatment.Actin filament-associated protein 1-antisense RNA 1(AFAP1-AS1)was initially identified as a carcinogenic lncRNA in esophageal adenocarcinoma,and later as a carcinogenic regulator of various malignant tumors.The abnormal overexpression of AFAP1-AS1 can regulate the proliferation,apoptosis,invasion and metastasis of tumor cells through different molecular mechanisms.The upregulation of AFAP1-AS1 in tumor tissues has important clinical significance.Understanding the function and mechanism of this lncRNA in cancers can further help to explore new strategies for the prevention and treatment of malignant tumors.Therefore,this paper reviewed the effects,relevant molecular mechanisms and potential clinical significance of AFAP1-AS1 in multiple human malignant tumors,so as to provide a scientific theoretical basis for its early clinical application.