文献类型：期刊文献

英文题名：Use peripheral blood leukocyte parameters combined with inflammatory indicators in diagnosis and severity assessment of mycoplasma pneumoniae pneumonia in children

作者：Zhang, Yuwen[1];Zhai, Yuanpeng[1];Qi, Shuai[1];Huang, Dan[1];Wang, Jingjing[1,2];Wang, Linyan[2];Dong, Xuemei[2];Sun, Zhipeng[3];Yin, Jiaojiao[2];Zhang, Chong[1,2]

第一作者：Zhang, Yuwen

通信作者：Zhang, C[1];Yin, JJ[2];Zhang, C[2]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Matern & Child Care Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China;[3]Sysmex Shanghai Ltd, Dept Sci & Applicat, Shanghai, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Matern & Child Care Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2025

卷号：20

期号：6

外文期刊名：PLOS ONE

收录：;Scopus(收录号：2-s2.0-105007333389);WOS:【SCI-EXPANDED(收录号:WOS:001502147400047)】；

基金：This study was supported by the Natural Science Foundation of Gansu Province (22JR5RA716, https://kjt.gansu.gov.cn/), Jiaojiao Yin works as the host of this funder, was responsible for the conceptualization, writing-review and editing of the manuscript. Gansu Provincial Science and Technology Major Special Program Project (22ZD6FA034, https://kjt.gansu.gov.cn/), Weikai Wang works as the host of this funder, had had no role in study design, data collection and analysis, decision to publish, or preparation of manuscript.

语种：英文

摘要：Background Mycoplasma pneumoniae is a common cause of pneumonia in children over 5 years of age. Cell Population Data (CPD) is valuable for screening various diseases, including certain infections and myeloproliferative disorders, but less used in the diagnosis of children mycoplasma pneumoniae pneumonia (MPP). Aims To improve the diagnostic efficacy and severity assessment of MPP in children by combining CPD with inflammatory markers. Methods This study was conducted at the Gansu Provincial Maternity and Child-care Hospital, China. The data was accessed on 01.10.2024 for the purpose of research. A retrospective study from 01.10. 2022-01.01.2024 included three groups of children aged 5-9 years: 1) those with MPP (n = 240), of which 73 were mild, 167 were severe; 2) those with bacterial pneumonia (n = 52); and 3) those with health check-ups (n = 340). CPD indicators were measured by Sysmex XN-9000 (Kobe, Japan) hematology analyzer. Inflammatory markers included PCT (procalcitonin), LDH (lactate dehydrogenase), CK-MB (creatine kinase isoenzyme), CRP (c-reactive protein), SAA (serum amyloid A), APTT (activated partial thromboplastin time), FIB (fibrinogen). The differences and correlation of parameters between three groups were analyzed and receiver operating characteristic (ROC) analysis was performed. Results Most of the leukocyte parameter indices showed statistically significant differences between the MPP group and the healthy physical examination group (p < 0.05). Compared with bacterial pneumonia group, inflammatory markers were not correlated with the occurrence of MPP (p > 0.05), while LY-X and NE-WY were negatively correlated with the occurrence of MPP (p < 0.05). ROC analysis showed that the areas under the curve (AUC) for LY-X and NE-WY were 0.707 and 0.736, respectively. Additionally, LY-WY and MO-WZ are positively correlated with the severity of MPP (p < 0.05), and the AUC for MO-WZ was 0.709. Among the inflammatory markers, the AUC for SAA was 0.828, and combining SAA with MO-WZ increased the AUC to 0.861 in distinguishing mild from severe MPP. Conclusion Peripheral blood leukocyte parameters may have clinical application value for the early diagnosis and disease progression assessment of MPP.