文献类型：期刊文献

中文题名：扶元补脑冲剂对老年性痴呆鼠脑ATP酶及脂质过氧化反应的影响

英文题名：Study on pharmacodynamics effect of Fuyuanbunao Granules on ATPase activities and lipid peroxidation in Alzheimer' disease mouse

作者：刘永琦[1];何建成[2];安耀荣[1];刘雄[1]

第一作者：刘永琦

机构：[1]甘肃中医学院,甘肃兰州730000;[2]上海中医药大学,上海201203

第一机构：甘肃中医药大学

年份：2004

卷号：26

期号：2

起止页码：130

中文期刊名：中成药

外文期刊名：Chinese Traditional Patent Medicine

收录：CSTPCD;;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

基金：甘肃省教育厅立项研究课题 (0 0B 12 )

语种：中文

中文关键词：老年性痴呆;扶元补脑冲剂;脑;自由基;ATP酶;脑系数

外文关键词：Alzheimer' disease; Fuyuanbunao Granules; ATPase; SOD; MDA; quotient of brain

摘要：目的 :研究扶元补脑冲剂 (红参、山楂、黄芪、淫羊藿、丹参、泽泻、石菖蒲 )对老年性痴呆鼠脑ATP酶活性、自由基含量及脑系数的影响。方法 :以三氯化铝痴呆模型小鼠为研究对象 ,探讨了扶元补脑冲剂对小鼠脑组织的MDA含量、Na+ K+ ATP酶、Mg2 + ATP酶活性、脑系数及血清SOD活性的影响。结果 :与模型组比较 ,扶元补脑冲剂能显著提高小鼠脑Na+ K+ ATP酶、Mg2 + ATP酶及血清SOD的活性以及脑系数 ,降低脑MDA含量。结论 :提示增强脑组织ATP酶的活性及机体抗脂质过氧化可能是扶元补脑冲剂防治老年性痴呆的作用机制之一。
AIM: To study effects of Fuyuanbunao Granules (Radix Ginseng Rubra, Fructus Crataegi, Radix Astragali, Herba Epimedii, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Rhizoma Acori Tatarinowii) on ATPase activities, MDA level in mouse brain, SOD activities in mouse blood and the quotient of brain. METHODS: On the mouse model of Alzheimer' disease toxified with AlCl 3, the effects of Fuyuanbunao Granules on Na + K + ATPase, Mg 2+ ATPase activities and MDA level in mouse brain, SOD activities in mouse blood were evaluated with spectroscopic analysis, and the weight of brain was measured with analytical balance. RESULTS: Compared with Alzheimer'disease model team, Fuyuanbunao Granules enhance the activities of Na +、K + ATPase, Mg 2+ ATPase, decease MDA level in the mouse brain and enhance the activities of SOD in blood. It also increases the weight of brain. CONCLUSION: It indicates that enhancing the activity of ATPase and deceasing peroxide level may be one of the mechanism for Fuyuanbunao Granules to prevent and cure Alzheimer' disease.