文献类型：期刊文献

中文题名：“脑肠同调”法针刺治疗急性脑梗死及对IL-17、hs-CRP和TMAO水平的影响

英文题名：Naochang Tongtiao acupuncture based on brain-gut axis for acute ischemic stroke and its effect on levels of IL-17, hs-CRP and TMAO

作者：王慧[1,2];雷寿清[3];杜小正[4];袁博[1,2];刘敏科[5]

第一作者：王慧

机构：[1]甘肃中医药大学附属医院针灸科,兰州730030;[2]甘肃省皇甫谧针灸医院,兰州730030;[3]甘肃中医药大学附属医院康复骨科,兰州730030;[4]甘肃中医药大学针灸推拿学院;[5]甘肃中医药大学附属医院神经内科,兰州730030

第一机构：甘肃中医药大学第二附属医院

年份：2022

卷号：42

期号：8

起止页码：853

中文期刊名：中国针灸

外文期刊名：Chinese Acupuncture & Moxibustion

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；PubMed;

基金：甘肃省科技计划项目:20YF8WA097;甘肃省皇甫谧针灸医院科研孵化项目:针院发[2020]1-4。

语种：中文

中文关键词：急性脑梗死;“脑肠同调”法针刺;美国国立卫生院卒中量表(NIHSS)评分;白细胞介素17(IL-17);超敏C反应蛋白(hs-CRP);氧化三甲胺(TMAO)

外文关键词：acute ischemic stroke;Naochang Tongtiao acupuncture;National Institution of Health stroke scale(NIHSS)score;interleukin-17(IL-17);hypersensitive C reactive protein(hs-CRP);trimethylamine oxide(TMAO)

摘要：目的:比较“脑肠同调”法针刺与常规针刺治疗急性脑梗死的临床疗效,并探讨其作用机制。方法:将64例急性脑梗死患者随机分为观察组和对照组,每组32例。两组均采用西医基础治疗,观察组予“脑肠同调”法针刺治疗,穴取顶颞前斜线、中脘、关元、天枢、足三里、上巨虚、下巨虚;对照组予常规针刺治疗,均每日1次,每周治疗6 d,共治疗3周。比较两组患者治疗前后美国国立卫生院卒中量表(NIHSS)评分,血清白细胞介素17(IL-17)、超敏C反应蛋白(hs-CRP)水平,及血浆氧化三甲胺(TMAO)水平。结果:治疗后,两组患者NIHSS评分,血清IL-17、hs-CRP水平,血浆TMAO水平均较治疗前降低(P<0.01),且观察组低于对照组(P<0.05)。结论:“脑肠同调”法针刺可改善急性脑梗死患者神经功能,疗效优于常规针刺。其机制可能与调节炎性反应及肠道菌群代谢产物水平有关。
Objective To compare the clinical therapeutic effect on acute ischemic stroke between Naochang Tongtiao acupuncture(acupuncture for brain-gut homology) and conventional acupuncture, and to explore the possible mechanism. Methods A total of 64 patients with acute ischemic stroke were randomized into an observation group and a control group, 32 cases in each one. Basic western medical therapy was adopted in both groups. In the observation group,Naochang Tongtiao acupuncture was applied at anterior oblique line of vertex-temporal, Zhongwan(CV 12), Guanyuan(CV 4), Tianshu(ST 25), Zusanli(ST 36), Shangjuxu(ST 37) and Xiajuxu(ST 39). In the control group, conventional acupuncture was applied. The treatment was given once a day, 6 days a week for 3 weeks in both groups. Before and after treatment, National Institution of Health stroke scale(NIHSS) score, serum levels of interleukin-17(IL-17) and hypersensitive C reactive protein(hs-CRP), and plasma level of trimethylamine oxide(TMAO) were compared in the two groups. Results After treatment, NIHSS scores, serum levels of IL-17 and hs-CRP, and plasma levels of TMAO were decreased compared before treatment in both groups(P<0.01), and those in the observation group were lower than the control group(P<0.05). Conclusion Naochang Tongtiao acupuncture can improve the nerve function in patients with acute ischemic stroke, its therapeutic effect is superior to conventional acupuncture, the mechanism may relate to the regulation on inflammatory reaction and the level of intestinal flora metabolite.