文献类型：期刊文献

中文题名：重构本草——牛膝

英文题名：Reconstruction of Chinese materia medica-twotoothed achyranthes root

作者：周凌[1,2];张湘苑[1,2];金籽杉[1,2];罗金丽[3];张伟[4,5]

第一作者：周凌

机构：[1]北京中医药大学,北京100029;[2]中国中医科学院广安门医院,北京100053;[3]广东一方制药有限公司,广东佛山528244;[4]甘肃中医药大学基础医学院,兰州730000;[5]中国中医科学院广安门医院代谢病研究所,北京100053

第一机构：北京中医药大学,北京100029

年份：2023

卷号：43

期号：2

起止页码：218

中文期刊名：吉林中医药

外文期刊名：Jilin Journal of Chinese Medicine

收录：CSTPCD

基金：中国科学院学部咨询评议项目(2021-ZW10-A-017)。

语种：中文

中文关键词：牛膝;症靶;标靶;血压;老年眩晕;下肢疼痛;肌肉萎缩;临床回归

外文关键词：twotoothed achyranthes root;symptom targets;biochemical indicator targets;blood pressure;senile vertigo;pain in lower limb;muscular atrophy;clinical verification

摘要：通过对古籍文献、中药现代研究及其成果的梳理,结合中医临床及中药学等学科领域专家学者的认识及应用经验,经讨论认为牛膝的功效主要为逐瘀通经,补肝肾,强筋骨,利尿通淋,引血下行。症靶为眩晕、下肢疼痛、肌肉萎缩。标靶为高血压、下肢静脉血栓。现代药理发现牛膝及其有效成分具有降压、神经保护、免疫调节、抗肿瘤、降血脂等作用。本品无毒,但是孕妇慎用。临床使用剂量为5.55~140 g,根据疾病、证型、症状等,灵活加减牛膝用量,并积极探索牛膝用量与症靶、病靶的量效关系构建。
Through combing the ancient literature,modern research on traditional Chinese medicine and its achievements,combined with the understanding and application experience of experts and scholars in the subject fields of clinical and traditional Chinese medicine,it is believed that twotoothed achyranthes root has the following characteristics:Its activities are mainly removing blood stasis for promoting menstruation,nourishing the liver and kidneys,strengthening tendons and bones,promoting diuresis and freeing stranguria,and directing blood to flow downward.Its symptom targets are vertigo,pains in lower limbs and muscular atrophy,while its biochemical indicator targets are hypertension and lower extremity venous thrombosis.Modern pharmacology has found that twotoothed achyranthes root and its active ingredients have the effects on hypotension,neuroprotection,immune regulation,antitumor,and lowering blood lipids.This product is non-toxic,but should be used with caution in pregnant women.Its clinical dosage range is 5.55-140 g.According to varying diseases,syndrome types and symptoms,its dosage should be flexibly added or subtracted,and the dose-effect relationship between its dosage and the symptom targets and biochemical indicator targets should be actively explored.