文献类型：期刊文献

英文题名：Air pollution-driven key regulators in hepatocellular carcinoma: Identification via integrated bioinformatics and network toxicology

作者：Wu, Yang[1,2,3];Li, Tian[3,4];Zhang, Jiucong[1];Zheng, Xiaofeng[5];Yu, Xiaohui[1]

第一作者：吴艳;武燕;Wu, Yang

通信作者：Wu, Y[1];Zhang, JC[1];Yu, XH[1];Wu, Y[2];Wu, Y[3];Zheng, XF[4]

机构：[1]940 Hosp Joint Logist Support Force PLA, Dept Gastroenterol, Lanzhou 730050, Gansu, Peoples R China;[2]Pengzhou Jiuchi Town Hosp, Chengdu 611930, Sichuan, Peoples R China;[3]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[4]Qianfeng Dist Tradit Chinese Med Hosp, Guangan 638019, Sichuan, Peoples R China;[5]Lanzhou Univ Second Hosp, Dept Gastroenterol, Lanzhou 730030, Gansu, Peoples R China

第一机构：940 Hosp Joint Logist Support Force PLA, Dept Gastroenterol, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), 940 Hosp Joint Logist Support Force PLA, Dept Gastroenterol, Lanzhou 730050, Gansu, Peoples R China;[2]corresponding author), Pengzhou Jiuchi Town Hosp, Chengdu 611930, Sichuan, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[4]corresponding author), Lanzhou Univ Second Hosp, Dept Gastroenterol, Lanzhou 730030, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

外文期刊名：TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES

收录：Scopus(收录号：2-s2.0-105036091234);WOS:【ESCI(收录号:WOS:001743958800001)】；

基金：Tutor Program at Gansu University of Traditional Chinese Medicine (2023YXKY020); Lanzhou Youth Science and Technology Talents Innovation Project (2024-QN-39); Key Research and Development Program of Gansu Province (22YF7FA105).

语种：英文

外文关键词：Air pollutants; Bioinformatics; Hepatocellular carcinoma; Molecular docking; Network toxicology

摘要：ObjectiveThis study aims to investigate the underlying molecular mechanisms linking seven prevalent air pollutants (benzene, toluene, SO2, NO2, NO, CO, and O3) to the development and occurrence of hepatocellular carcinoma (HCC).MethodsSeven kinds of air pollutants and HCC-related genes were retrieved from several online databases, and their intersections were taken. PPI visualization analysis of intersection genes was performed. The potential biological mechanism of intersection genes was clarified by GO and KEGG enrichment analysis. Using five different algorithms to identify the core gene, the expression level of core gene in HCC was verified by TCGA database, and its diagnostic performance was evaluated by the ROC curve. Through KM survival analysis, the genes related to prognosis were further screened, and the relationship between them and immune cell infiltration was explored. The interaction between them and seven air pollutants was explored by molecular docking analysis.ResultsSeven common air pollutants and HCC-related genes have 55 cross genes. The enrichment analysis of GO and KEGG showed that these genes promoted the occurrence and development of HCC through cell carcinogenesis, signal transduction, genetic information processing, and metabolic correlation. Eight core genes were screened by five different algorithms. TCGA data confirmed that the eight core genes were differentially expressed in HCC, and ROC curve showed that all the eight core genes had a good diagnostic performance. KM survival curve further showed that six key genes were related to the poor prognosis of HCC patients. Immune infiltration analysis revealed that these six key genes play significant roles in the HCC immune microenvironment. Molecular docking further supported potential interactions between the air pollutants and these six key genes.ConclusionThe findings indicate that ESR1, MMP9, RELA, PARP1, DNMT1, and CDK1 are critically involved in HCC pathogenesis. This research enhances public understanding of air pollution risks.