文献类型：期刊文献

英文题名：Targeting bone marrow mesenchymal stem cells with traditional Chinese medicine active ingredients: Restoring hematopoietic microenvironment homeostasis to prevent and treat myelosuppression

作者：Yan, Jingnan[1];Qi, Yafeng[1];Guo, Jiajun[2];Jiang, Xiaodan[1];Li, Jingwei[1];Wan, Jiayi[1];Xv, Qian[5];Zhang, Lumei[5];Li, Yangyang[3,4];Zhang, Liying[3,4];Zhang, Zhiming[1,5]

第一作者：Yan, Jingnan

通信作者：Zhang, LY[1];Zhang, ZM[1]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Sch Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Prov Key Lab Mol Med & Prevent Res Major Dis, Lanzhou 730000, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Key Lab Dunhuang Med & Translat, Educ Minist Educ, Lanzhou 730000, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, Dept Oncol, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2026

卷号：233

外文期刊名：PHARMACOLOGICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-105050503549);WOS:【SCI-EXPANDED(收录号:WOS:001881347200001)】；

基金：This work was supported by Lanzhou City Science and Technology Plan Project (2025-2-3); Gansu Provincial Silver Age Expert Studio (Party Committee Talent Group [2025] No. 4); National Natural Science Foundation of China funded project (82460925, 82260882) ; Project for Strengthening the Evidence-Based Research System of Traditional Chinese Medicine by the National Administration of Traditional Chinese Medicine (GZY-KJS-2026-002-043); Gansu Province Clinical Center for Evidence-Based Medicine of Traditional Chinese Medicine (Gan TCM Sci. & Edu. Letter [2025] No. 3, Gan TCM Sci. & Edu. Letter [2026] No. 1-3) ; Gansu Province Research Center for AI-Assisted TCM Inspection Engineering (Gan Development & Reform High Tech [2024] No. 738); Gansu University of Chinese Medicine Postgraduate Innovation and Entrepreneurship Fund Project (2026CXCY-027, 2026CXCY-033).

语种：英文

外文关键词：Natural products; Bone marrow mesenchymal stem cells; Myelosuppression; Hematopoietic microenvironment; Therapeutic potential

摘要：Myelosuppression is a common and dose-limiting severe complication in tumor radiotherapy and chemotherapy. The disruption of hematopoietic microenvironment homeostasis mediated by bone marrow mesenchymal stem cells (BMSCs) may be one of the important pathological factors for its persistent non-healing. Traditional Chinese medicine (TCM) can regulate BMSCs function through multi-target and multi-pathway mechanisms, reshape the hematopoietic microenvironment, and support hematopoietic regeneration. This article systematically explains the network mechanisms by which BMSCs regulate hematopoiesis and the pathological mechanisms by which factors like radiotherapy and chemotherapy damage BMSCs. It explores how active ingredients in Chinese medicine can restore BMSCs function and remodel the hematopoietic microenvironment by regulating differentiation and enhancing paracrine effects, suggesting that shifting treatment strategies from "protecting the seeds" to "remodeling the soil" might be a promising direction. At the same time, it summarizes the potential application value of nano-targeted delivery to improve bone marrow homing efficiency of active ingredients and other new technology research progress. Although most studies are still at the preclinical stage, these findings suggest the potential value of TCM in treating myelosuppression and provide ideas and directions for using single-cell multi-omics to identify abnormal BMSCs subpopulations and their molecular targets, developing intelligent drug delivery systems, and conducting clinical translational research.