文献类型：期刊文献

英文题名：Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

作者：Zhao, Jing[1];Liang, He[1];Li, Yanrong[2];Xu, Zimeng[3];Li, Xueqin[3];Zhao, Lulu[3];Zhang, Mengqian[3];Duan, Xuehui[3]

第一作者：Zhao, Jing

通信作者：Zhao, J[1];Li, YR[2]

机构：[1]Dingxi Peoples Hosp, Dingxi, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Gansu, Peoples R China;[3]Luoyang Normal Univ, Life Sci Coll, Luoyang, Henan, Peoples R China

第一机构：Dingxi Peoples Hosp, Dingxi, Gansu, Peoples R China

通信机构：[1]corresponding author), Dingxi Peoples Hosp, Dingxi, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Gansu, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2024

卷号：30

外文期刊名：MEDICAL SCIENCE MONITOR

收录：;Scopus(收录号：2-s2.0-85209362807);WOS:【SCI-EXPANDED(收录号:WOS:001377042700001)】；

基金：This work was supported by the National Natural Science Foundation of China [grant number 82360905]

语种：英文

外文关键词：Antioxidants; Chemical and Drug Induced Liver Injury; Oxidative Stress; Chinese Herbal Medicine

摘要：The liver serves as a crucial organ for detoxification and exhibits a robust regenerative capacity. The improper administration of pharmaceuticals frequently results in drug-induced liver injury (DILI), a condition closely associated with the overproduction of reactive oxygen species (ROS). In addressing DILI, Traditional Chinese Medicine (TCM) often employs plant-based remedies, which have demonstrated favorable therapeutic outcomes. These plant-based treatments are typically rich in antioxidants capable of neutralizing ROS. However, there is a notable lack of comprehensive reviews that synthesize the therapeutic effects of antioxidants derived from medicinal plants on DILI. The present review starts by exploring ROS generation and clearance in human health, then outlines DILI characteristics and treatments, emphasizing its strong link to oxidative stress. Furthermore, we discuss the properties and classification of antioxidants found in plant-based pharmaceuticals, with a particular emphasis on the synergistic effects of these antioxidants and their mechanisms for repairing DILI. Finally, we provide a summary of commonly utilized medicinal plants from TCM for the treatment of DILI. In conclusion, this article explores the future prospects and potential solutions for treating DILI using antioxidants found in plant-based drugs derived from TCM. The objective of this review is to examine the role of antioxidants in TCM and their impact on DILI.