文献类型：期刊文献

英文题名：Pharmacological Targeting of Type H Endothelial Cells in Knee Osteoarthritis: From Molecular Signaling to Cellular Homeostasis

作者：Yan, Chunlu[1];Sui, Chuangwei[2];Wan, Qiao[3];Liu, Xupeng[2];Fang, Zeling[3];Shi, Jiarong[3];Chen, Chen[3];Jiang, Yu[2];Yu, Juan[4];An, Fangyu[5]

第一作者：颜春鲁

通信作者：An, FY[1]

机构：[1]Gansu Univ Chinese Med, Dunhuang Med Acad, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[5]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：15

期号：14

外文期刊名：CELLS

收录：;Scopus(收录号：2-s2.0-105045961255);WOS:【SCI-EXPANDED(收录号:WOS:001831580900001)】；

基金：This work was financially supported by Gansu Joint Research Fund Project (Grant number: 24JRRA879), Gansu Natural Science Foundation (Grant number: 24JRRA1026), The Education University Teachers' Innovation Fund Project of Gansu Provincial Education Department (Grant number: 2026B-118), Dingxi Science and Technology Plan Project (Grant number: DX2024BY017), Higher Education Teaching Reform Research Project of Gansu Provincial (Grant number: GJJGB228), Graduate "Innovation and Entrepreneurship Fund" Project of Gansu University of Chinese Medicine (Grant number: 2026CXCY-212, 2026CXCY-236).

语种：英文

外文关键词：type H endothelial cells; vascular-osteogenic coupling; cell signaling; senolytics; small molecule modulators; knee osteoarthritis

摘要：The pathogenesis of knee osteoarthritis (KOA) involves bone homeostasis imbalance induced by inflammation, metabolism, age, mechanical stress, joint injury and other factors. Recently, Type H vessels (CD31(hi)EMCN(hi) endothelial cells) have emerged as a specialized endothelial cell subset that couples angiogenesis with osteogenesis. Type H angiogenesis in the diaphysis was found to be beneficial for maintaining bone homeostasis, while the abnormal proliferation of type H vessels in subchondral bone can lead to chondrocyte hypertrophy and osteophyte formation. However, the mechanism by which the abnormal proliferation of type H vessels induces KOA has not been elucidated in detail. In this review, we summarize the latest evidence on the role of type H endothelial cell function in the pathogenesis and progression of osteoarthritis (OA). We review the role of type H angiogenesis at different sites in the development and progression of OA and focus on the potential mechanisms that regulate type H angiogenesis in OA and the potential therapeutic value and significance of targeting type H angiogenesis in promoting bone regeneration and maintaining bone homeostasis. Finally, we discuss key obstacles and future directions for studying type H vessel regulation in KOA, offering an endothelial cell-based framework for understanding bone homeostasis and improving OA.