文献类型：期刊文献

英文题名：Effect of Different Local Antibiotic Regimens on Prevention of Postoperative Infection in Clean Surgical Wounds: A Systematic Review and Network Meta-analysis

作者：Pan, Hai Bang[1];Cui, Yan[1];Wu, Zhi Hang[1];Meng, Ying[1];Wang, Tian Ming[2];Fu, Qi[2];Chen, Qian[2];Chen, Quan Xin[2];Wang, Bo[2]

第一作者：潘海邦

通信作者：Pan, HB[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Nursing, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：37

期号：4

起止页码：216

外文期刊名：ADVANCES IN SKIN & WOUND CARE

收录：;Scopus(收录号：2-s2.0-85188565291);WOS:【SSCI(收录号:WOS:001280290800013)，SCI-EXPANDED(收录号:WOS:001280290800013)】；

语种：英文

外文关键词：antibiotic; clean wound; network meta-analysis; prevention; surgical site infection; surgical wound; topical

摘要：OBJECTIVETo compare the efficacy of several local antibiotic regimens in preventing surgical site infection (SSI) in clean surgical wounds.DATA SOURCESThe authors searched CNKI (China National Knowledge Infrastructure), the VIP (VIP information resource integration service platform), Wanfang Data knowledge service platform (WANFANG), SinoMed, Cochrane Library, EMBASE, and PubMed.STUDY SELECTIONA total of 20 randomized controlled trials published between January 1, 2000 and April 1, 2021 were included in this meta-analysis.DATA EXTRACTIONAuthors extracted the name of the first author, publication date, country, type of surgery, follow-up time, mean age of participants, sample size of each group, interventions, outcome indicators, and study type from each article.DATA SYNTHESISThe overall effectiveness of eight local managements in reducing the incidence of the SSI effect were compared through the SUCRA (surface under the cumulative ranking curve) probabilities. The results of a network meta-analysis demonstrated that gentamicin ointment (odds ratio [OR], 0.16; 95% CI, 0.04-0.60), mupirocin ointment (OR, 0.44; 95% CI, 0.21-0.94), and gentamicin soaking of the graft (OR, 0.63; 95% CI, 0.44-0.91) significantly reduced the incidence of SSI compared with control. Further, vancomycin soaking of the graft (86.7%) ranked first, followed by gentamicin ointment (81.1%), gentamicin irrigation (79.9%), mupirocin ointment (56.8%), triple antibiotic ointment (47.8%), gentamicin soaking of the graft (42.3%), and vancomycin powder (22.1%); ampicillin powder (17.8%) was the least effective drug.CONCLUSIONSThe findings indicate that local antibiotics combined with conventional antibiotics in the wound before wound closure are effective in reducing the incidence of SSI in clean surgical wounds. Vancomycin inoculation of the graft exhibited the best effect.