文献类型：期刊文献

英文题名：Development and evaluation of self-nanoemulsifying drug delivery system of rhubarb anthraquinones

作者：Li, Jincheng[1];Shi, Yanbin[1];Ren, Yuan[2];Cong, Zhaotong[1];Wu, Guotai[2];Chen, Nana[1];Zhao, Xiaoning[1];Li, Li[1]

第一作者：Li, Jincheng

通信作者：Shi, YB[1]

机构：[1]Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab TCM Pharmacol & Toxicol Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.

年份：2017

卷号：39

起止页码：283

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;Scopus(收录号：2-s2.0-85017241964);WOS:【SCI-EXPANDED(收录号:WOS:000404312200031)】；

基金：The authors acknowledge financial support from Key Laboratory of TCM Pharmacology and Toxicology of Gansu Province (ZDSYS-KJ-2013-005), TCM Science and Technology Research Project of Gansu (GZK-2015-3), P.R. China.

语种：英文

外文关键词：Rhubarb anthraquinones; Spontaneous nanoemulsification; Central composite design; Dissolution profile; Pharmacokineitics

摘要：Rhubarb anthraquinones (RhA) as a group were formulated in nanoemulsion based system with the aim of improving its solubility and oral bioavailability. RhA loaded nanoemulsion (RhA-NE) was prepared using spontaneous nanoemulsification method. Solubility of RhA in oils, surfactants and co-surfactants was determined to select nanoemulsion components. Surfactants and co-surfactants were screened for their ability to emulsify selected oily phase. Pseudo-ternary phase diagrams were constructed to identify area of nanoemulsification. A four-factor-five-level central composite design was carried out to attain optimal formulation. The optimized formulations of RhA-NE consisted of capryol 90/ethyl oleate containing RhA as oil phase, cremophor RH 40 as surfactant, transcutol HP as co-surfactant, oleic acid as stabilizer and distilled water as water phase. The RhA-NE was characterized by dynamic light scanning, transmission electron microscope, solubilizing capacity, encapsulation efficiency, drug loading and stability. The optimized RhA-NE can obviously enhance solubilization of RhA in distilled water. The appearance and RhA contents were basically unchanged after 60-day storage at room temperature in brown bottle. More than 50% RhA released from nanoemulsion within 240 h in vitro. Pharmacokinetics in rats showed that the C-max and AUC of RhA-NE were enhanced compared to that of RhA suspension. (C) 2017 Published by Elsevier B.V.