文献类型：期刊文献

中文题名：Optimal Formula of Angelica sinensis Ameliorates Memory Deficits in β-amyloid Protein-induced Alzheimer's Disease Rat Model

作者：Hu-ping WANG[1];Hong-yan WU[1];Chun-lin MA[1];Qing-tao ZENG[1];Kai-min ZHU[1];Shu-mei CUI[1];Hai-long LI[2];Guo-tai WU[3];Zhi-wei WU[1];Jian-zheng HE[1]

第一作者：Hu-ping WANG

机构：[1]Basic Medicine College,Gansu University of Chinese Medicine,Lanzhou 730000;[2]Clinical Medicine College,Gansu University of Chinese Medicine,Lanzhou 730000;[3]Pharmacy College,Gansu University of Chinese Medicine,Lanzhou 730000

第一机构：甘肃中医药大学

年份：2022

卷号：42

期号：1

起止页码：39

中文期刊名：当代医学科学(英文)

外文期刊名：Current Medical Science

收录：Scopus;PubMed

基金：This project was supported by the National Natural Science Foundation of China(No.81960828).

语种：英文

中文关键词：optimal formula of Angelica sinensis;Alzheimer's disease;amyloid P aggregation;oxidative stress;neuroinflammation

摘要：Objective:Angelica(A.)sinensis is used as a traditional medical herb for the treatment of neurodegeneration,aging,and inflammation in Asia.A.sinensis optimal formula(AOF)is the best combination in A.sinensis that has been screened to rescue the cognitive ability in P-amyloid peptide(Ap25-35)-treated Alzheimer’s disease(AD)rats.The objective of this study was to investigate the effect of AOF on the learning and memory of AD rats as well as to explore the underlying mechanisms.