文献类型：期刊文献

英文题名：The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17/regulatory Tcells in rheumatoid arthritis

作者：Wang, Tao[1];Wang, Zhandong[1];Qi, Wenxia[1];Jiang, Ganggang[1];Wang, Gang[2,3]

第一作者：王涛;王韬

通信作者：Wang, G[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：26

期号：4

起止页码：613

外文期刊名：INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES

收录：;Scopus(收录号：2-s2.0-85147034439);WOS:【SCI-EXPANDED(收录号:WOS:000918266500001)】；

基金：This work received support from National Natural Science Foundation of China (81860858 and 81960832), Youth Science and technology Fund of Science and Technology Department of Gansu Province 21JR11RA158

语种：英文

外文关键词：mechanism of action; rheumatoid arthritis; T helper type 17; regulatory T cells; traditional Chinese medicine

摘要：Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease, having all the hallmarks of joint swelling, joint tenderness, and progressive joint destruction, with synovitis and pannus formation as the basic pathological changes. T-lymphocyte infiltration is the key to its pathogenesis. During the growth of RA, the share of regulatory T (Treg) cells decreases, while the percentage of T helper type 17 (Th17) cells increases, giving rise to an imbalance of Th17/Treg cells. Modern medicine has made great advances in the treatment of RA and the selection of available drugs, but there are also the disadvantages of gastrointestinal reaction, high price, and low patient compliance. Therapy of RA remains a problem. Traditional Chinese medicine (TCM) has RA therapy developments, both in experimental research and clinical research, and its advantages of lasting effects and less detrimental reactions and fewer adverse effects are accepted by most patients. Numerous clinical and experimental studies have been performed in TCM on regulating Th17/Treg balance. However, the detailed mechanism of TCM intervention in Th17/Treg equilibrium in preventing and treating RA has not been discovered. In this article, the theory of regulating Th17/Treg cell equilibrium in RA is described from the perspectives of single Chinese medicine, active components of Chinese medicine, Chinese medicine compounds, and other therapies of TCM. It was found that TCM can regulate Th17/Treg cell balance and inhibit immunoreaction by intervening in cytokines, transcription factors, and signal pathways. It enables us to comprehensively and deeply understand the mechanism of TCM intervening in Th17/Treg balance in RA; provides direction for clinical therapy of RA; and offers new thoughts for understanding the pathogenesis of RA.