文献类型：期刊文献

中文题名：敦煌下瘀血方对盆腔炎性疾病后遗症模型大鼠血细胞因子的影响

英文题名：Efficacy of the Dunhuang Xiayuxue prescription on blood cytokines on rats with sequela of pelvic inflammatory disease

作者：张小花[1];申剑[1];武权生[1];刘培霞[2]

第一作者：张小花

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]榆中县中医院,甘肃兰州730100

第一机构：甘肃中医药大学

年份：2019

卷号：11

期号：22

起止页码：11

中文期刊名：中医临床研究

外文期刊名：Clinical Journal Of Chinese Medicine

基金：2014年甘肃省高等学校科研项目（项目编号：2014A-079）;甘肃省高校人文社科重点研究基地敦煌医学文献整理与应用研究中心开放基金项目（项目编号：DHYX2014-06）

语种：中文

中文关键词：敦煌下瘀血方;盆腔炎性疾病后遗症;白细胞介素-2;白细胞介素-1β

外文关键词：The Dunhuang Xiayuxue prescription;Sequelae of pelvic inflammatory disease;IL-2;IL-1β

摘要：目的:探讨敦煌下瘀血方对盆腔炎性疾病后遗症模型大鼠影响。方法:将50只SPF级雌性SD大鼠随机分为空白组、模型组及低剂量组、中剂量组、高剂量组,除空白组外均进行盆腔炎性疾病后遗症造模。造模30天后,空白组及模型组予以生理盐水4 mL,高剂量组、中剂量组、低剂量组则灌服下瘀血方,每天一次,共15天。结果:灌药结束后,除模型组外,其余各组大鼠体重均较造模前有增长,与造模前相比较P分别<0.05、<0.01;而模型组与其余各组比较,体质量较低,P<0.01。与模型组相比较,空白组、中剂量组和高剂量组大鼠血白细胞介素-2(Interleukin-2,IL-2)升高,空白组、高剂量组血白细胞介素-1β(Interleukin-1,IL-1β)降低,P<0.05、P<0.01;与空白组、高剂量组相比,低剂量组大鼠血IL-2降低、中剂量大鼠血IL-1β升高,P<0.05、P<0.01;高剂量组大鼠血IL-1β与低剂量组相比较,P<0.05。结论:敦煌下瘀血方能使盆腔炎性疾病后遗症模型大鼠血IL-2升高、IL-1β降低。
Objective: To investigate the effects of the Dunhuang Xiayuxue prescription (敦煌下瘀血方) on rats with sequela of pelvic inflammatory disease. Methods: Fifty female Sprague-Dawley rats were randomly divided into the blank group, the model group, the low-dose group, the middle-dose group, and the high-dose group. All the sequelae of pelvic inflammatory disease were modeled except the blank group. After 30 days of modeling, the blank group and the model group were given 4 mL of normal saline. The high-dose group, the middle-dose group and the low-dose group were given the Dunhuang Xiayuxue prescription. Results: After the filling, except for the model group, the body weight in the other groups was increased compared with that before the model establishment, P<0.05, P<0.01. That in the model group was lowest, P< 0.01. Compared with the model group, the blood IL-2 level was increased in the blank group, the middle dose group and the high dose group. The blood IL-1β was decreased in the blank group and the high dose group, P<0.05, P<0.01. Compared with the blank group and the high dose group, the serum IL-2 level was decreased in the low dose group, and serum IL-1β increased in the medium-dose rat, P<0.05, P<0.01. Conclusion: The Dunhuang Xiayuxue prescription can increased blood IL-2 and decrease IL-1β in rats with sequela of pelvic inflammatory disease.