文献类型：期刊文献

英文题名：Advances in Exosomal microRNAs and Proteins in Ovarian Cancer Diagnosis, Prognosis, and Treatment

作者：Qin, Tiansheng[1,2];Chen, Fan[1,2];Zhu, Jiaojiao[1,2];Ding, Yaoyao[1,2];Zhang, Qianqian[1,2]

第一作者：Qin, Tiansheng

通信作者：Qin, TS[1];Qin, TS[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：23

期号：6

起止页码：509

外文期刊名：CURRENT MOLECULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-85140755645);WOS:【SCI-EXPANDED(收录号:WOS:001005594400003)】；

语种：英文

外文关键词：Exosomes; microRNAs; proteins; ovarian cancer; diagnosis; prognosis; therapy; drug resistance

摘要：Late diagnosis, postoperative recurrence, and chemotherapy resistance are the main causes of the high mortality rate in ovarian cancer (OC). Understanding the molecular mechanisms in the pathogenesis and progression of OC may contribute to discovering new tumor biomarkers and therapeutic targets for OC. Exosomes are small extracellular vesicles derived from different types of cells that carry cargos, including nucleic acids, proteins, and lipids, and are pivotal mediators of intercellular communication in the tumor microenvironment. There is emerging evidence that exosomal proteins and nucleic acids play pivotal roles in facilitating the progression and drug resistance of OC. Identification of these factors may aid in the future diagnosis of OC. Furthermore, they also have promising value as OC therapeutic targets that can improve the prognosis. In the current review, we summarize the progress of exosomal research in OC, especially highlighting the most updated roles of exosomal microRNAs and proteins in the diagnosis, prognosis, therapy, and drug resistance of OC in order to facilitate future studies in this area.