文献类型：期刊文献

英文题名：Regulation and mechanism of Astragalus polysaccharide on ameliorating aging in Drosophila melanogaster

作者：Li, Xu[1,5];Yang, Shipei[2,3];Wang, Shuwei[1];Shi, Yan[2,3];Dai, Yuting[1];Zhang, Xueyan[1];Liu, Yongqi[2,4];Guo, Yaqiong[6];He, Jianzheng[2,3,4];Xiu, Minghui[1,4]

第一作者：Li, Xu;许丽

通信作者：Xiu, MH[1];He, JZ[2];He, JZ[3]

机构：[1]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent Tre, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial L, Lanzhou 730000, Peoples R China;[5]Lanzhou Univ, Hosp 1, Inst Infect, Lanzhou 730000, Peoples R China;[6]Second Prov Peoples Hosp Gansu, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent Tre, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;

年份：2023

卷号：234

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;Scopus(收录号：2-s2.0-85148761468);WOS:【SCI-EXPANDED(收录号:WOS:000948066300001)】；

基金：Funding The authors appreciated the financial support received from the National Natural Science Foundation of China (Nos. 82104562, 82004228) , Gansu Planning Projects on Science and Technology (No. 20JR10RA332) . Talent Introduction Project from Gansu University of Chinese Medicine (No. 2018YJRC-12) .

语种：英文

外文关键词：Astragalus polysaccharide; Intestinal homeostasis; Intestinal stem cells; Sleeping disturbances; Alzheimer's disease; Drosophila melanogaster

摘要：Astragalus polysaccharide (APS) is a notable bioactive component of Astragalus membranaceus and has been extensively investigated for its pharmacological activities, including antioxidant, neuroprotection, and anti-cancer effects. However, the beneficial effects and mechanisms of APS on anti-aging diseases remain largely unknown. Here, we utilized the classic model organism Drosophila melanogaster to investigate the beneficial effects and mechanism of APS on aging-related intestinal homeostasis imbalance, sleeping disorders, and neurodegenerative diseases. The results showed that administration of APS significantly attenuated age-associated disruption of the intestinal barrier, loss of gastrointestinal acid-base balance, reduction in intestinal length, overproliferation of the intestinal stem cells (ISCs), and sleeping disorders upon aging. Furthermore, APS supplementation delayed the onset of Alzheimer's phenotypes in A beta 42-induced Alzheimer's disease (AD) flies, including the extension of lifespan and the increase in motility, but without rescuing neurobehavioral deficits in the AD model of taupathy and Parkinson's disease (PD) model of Pink1 mutation. In addition, transcriptomics was used to dissect updated mechanisms of APS on anti-aging, such as JAK-STAT signaling, Toll signaling, and IMD signaling pathways. Taken together, these studies indicate that APS plays a beneficial role in modulating aging-related diseases, thereby as a potential natural drug to delay aging.