文献类型：期刊文献

中文题名：自身免疫性肝病基于肠道菌群的靶向治疗最新进展

英文题名：Latest research advances in intestinal flora-based targeted therapy for autoimmune liver disease

作者：张照杰[1,2];张婷[1,2];李向向[1,2];郭会姬[1,2];王振[1,2];杨妹霞[1,2];寇春焕[1,2];赵勇[3];于晓辉[2];张久聪[2]

第一作者：张照杰

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730000;[3]中国人民解放军联勤保障部队第九四〇医院卫勤训练中心,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：41

期号：12

起止页码：2629

中文期刊名：临床肝胆病杂志

外文期刊名：Journal of Clinical Hepatology

收录：;北大核心:【北大核心2023】；

基金：甘肃省卫健委课题(GSWSKY2023-34);兰州市青年科技人才创新项目(2024-QN-39)。

语种：中文

中文关键词：自身免疫性肝病;胃肠道微生物组;靶向治疗

外文关键词：Autoimmune Liver Disease;Gastrointestinal Microbiome;Targeted Therapy

摘要：自身免疫性肝病(AILD)的发病机制尚未完全阐明,导致其临床疗效存在显著个体差异。近年来的研究表明,肠道菌群及其代谢物通过“肠-肝轴”与AILD发生发展和发病机制之间存在密切关联,基于肠道菌群的靶向治疗方法为治疗AILD患者提供新的策略。本文系统综述了肠道菌群在AILD中的潜在致病机制及靶向治疗策略的最新研究进展,通过解析菌群失衡介导免疫紊乱的分子机制,探讨靶向调控肠道微生态实现治疗的可能性,以期为临床诊疗提供理论依据和转化方向。
The pathogenesis of autoimmune liver disease(AILD)remains unclear,leading to significant individual differences in clinical outcomes.Recent studies have shown that intestinal flora and its metabolites are closely associated with the development,progression,and pathogenesis of AILD through the gut-liver axis,and targeted therapy based on intestinal flora has provided new strategies for the treatment of AILD.This article systematically reviews the potential pathogenic mechanism of intestinal flora in AILD and the latest research advances in targeted therapeutic strategies and explores the possibility of targeted regulation of intestinal microecology to achieve treatment by analyzing the molecular mechanisms of immune disorders mediated by imbalance of intestinal flora,in order to provide a theoretical basis for clinical diagnosis and treatment.