文献类型：期刊文献

英文题名：A review on the structure and pharmacological activity of phenylethanoid glycosides

作者：Tian, Xiu-Yu[1,2];Li, Mao-Xing[1,2,3];Lin, Tong[2];Qiu, Yan[4];Zhu, Yu-Ting[5];Li, Xiao-Lin[2,3];Tao, Wen-Di[1,2];Wang, Peng[2,3];Ren, Xiao-Xia[6];Chen, Li-Ping[2]

第一作者：Tian, Xiu-Yu

通信作者：Li, MX[1]

机构：[1]Lanzhou Univ, Sch Pharm, Lanzhou 730030, Peoples R China;[2]940th Hosp Joint Logist Support Force PLA, Dept Clin Pharm, Lanzhou 730050, Peoples R China;[3]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730030, Peoples R China;[4]Shanghai Hlth Univ, Dept Pharm, Pudong New Area Peoples Hosp, Shanghai 201299, Peoples R China;[5]3201 Hosp, Dept Pharm, Hanzhong 723000, Shaanxi, Peoples R China;[6]Northwest Normal Univ, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Sch Pharm, Lanzhou 730030, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force PLA, Dept Clin Pharm, Lanzhou 730050, Peoples R China.

年份：2021

卷号：209

外文期刊名：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85092110978);WOS:【SCI-EXPANDED(收录号:WOS:000600418500002)】；

基金：This study was supported by Emergency Medical Research Project of "Novel Coronavirus Pneumonia (COVID-19)" (20yjky018); a seed fund of Shanghai University of Medicine & Health Sciences to study on the mechanism of acteoside in relieving brain edema caused by air transport injury (SFP-18-21-13-004); Construction of Technical platform for Clinical Evaluation and Research of New Anti-Stroke drugs, a key Project of Collaborative Innovation in Shanghai University of Medicine & Health Sciences (SPCI-18-13001), the Fundamental Research Funds for the Central Universities (31920200010).

语种：英文

外文关键词：Phenylethanoid glycosides; Biochemical synthesis; Content determination; Separation and purification; Pharmacological activities; Toxicity

摘要：Phenylethanoid glycosides (PhGs) are compounds made of phenylethyl alcohol, caffeic acid and glycosyl moieties. The first published references about phenylethanoid glycosides concerned the isolation of echinacoside from Echinaceu ungustifolia (Asteraceae) in 1950 and verbascoside from Verbascum sinuatum (Scrophulariaceae) in 1963. Over the past 60 years, many compounds with these structural characteristics have been isolated from natural sources, and most of these compounds possess significant bioactivities, including antibacterial, antitumor, antiviral, anti-inflammatory, neuro-protective, antioxidant, hepatoprotective, and immunomodulatory activities, among others. In this review, we will summarize the phenylethanoid glycosides described in recent papers and list all the compounds that have been isolated over the past few decades. We will also attempt to present and assess recent studies about the separation, extraction, determination, and pharmacological activity of the excellent natural components, phenylethanoid glycosides. (c) 2020 Elsevier Masson SAS. All rights reserved.