文献类型：期刊文献

英文题名：Laparoscopy-assisted versus open distal gastrectomy for early gastric cancer: A meta-analysis based on seven randomized controlled trials

作者：Deng, Yuan[1];Zhang, Yan[2];Guo, Tian-Kang[2]

第一作者：邓毅

通信作者：Guo, TK[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Lanzhou, Peoples R China.

年份：2015

卷号：24

期号：2

起止页码：71

外文期刊名：SURGICAL ONCOLOGY-OXFORD

收录：;Scopus(收录号：2-s2.0-84930927619);WOS:【SCI-EXPANDED(收录号:WOS:000355679200003)】；

语种：英文

外文关键词：Laparoscopy-assisted distal gastrectomy (LADG); Open distal gastrectomy (ODG); Early gastric cancer (EGC); Meta-analysis

摘要：Objective: This study aims to answer the superiority of comparing laparoscopy-assisted distal gastrectomy (LADG) with open distal gastrectomy (ODG) in the treatment early gastric cancer (EGC). Material and methods: A comprehensive search up to May 31, 2014 was conducted on PubMed, Web of science, and the Cochrane Library. All eligible studies comparing LADG versus ODG were included. Data synthesis and statistical analysis were performed using RevMan 5.2 software. Results: Seven randomized controlled trials (RCTs) totaling 390 patients (195 LADG and 195 ODG) were analyzed. Compared to ODG, LADG showed longer operative time (WMD = 79.60; 95% CI = 59.86 to 99.35; P < 0.00001), but was associated with less blood loss (WMD = -108.11; 95% CI = -145.97 to -70.26; P < 0.00001), fewer administered analgesics (WMD = -1.70; 95% CI = -2.19 to -1.22; P < 0.00001), fewer number of harvested lymph node (WMD = -2.77; 95% CI = -4.38 to -1.16; P = 0.0007), lower incidence of postoperative complications (OR = 0.26; 95% CI = 0.13 to 0.54; P = 0.0003), shorter postoperative hospital stay (WMD = -1.0; 95% CI = -1.83 to -0.16; P = 0.02) and earlier passage of flatus (WMD - -0.62; 95% CI - -0.96 to -0.27; P - 0.0005). Conclusion: This meta-analysis demonstrated that LADG significantly reduced blood loss, decreased the frequency of analgesic administration, faster recovery, a shorter hospital stay and fewer postoperative complications compared with ODG, though at the price of longer operative times and the number of harvested lymph nodes lesser as compared to ODG. (C) 2015 Elsevier Ltd. All rights reserved.