文献类型：期刊文献

英文题名：Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP

作者：Qi, Peng[1];Xie, Ruixuan[2];Liu, Hao[1];Zhang, Zixuan[1];Cheng, Yuan[1];Ma, Jilong[1];Wan, Kangwei[1];Xie, Xingwen[1,3]

第一作者：Qi, Peng

通信作者：Xie, XW[1];Xie, XW[2]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Wenzhou Med Univ, Wenzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85213036859);WOS:【SCI-EXPANDED(收录号:WOS:001383577500001)】；

基金：The authors acknowledge the use of Biorender to create schematic representations in Figures 1 - 3 . The agreement numbers associated with this use are ZN27AVF0IQ,UE27AVF81Y,ON27AVFD2P.

语种：英文

外文关键词：gut homeostasis; Th17/Treg cell balance; PMOP; mechanism study; gut microbiome

摘要：Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency, primarily manifesting as reduced bone mass and heightened fracture risk. Its development is intricately linked to the balance between Th17 and Treg cells. Recent studies have highlighted the significant role of gut homeostasis in PMOP. The gut microbiota profoundly impacts bone health by modulating the host's immune system, metabolic pathways, and endocrine functions. In particular, the regulation of Th17 and Treg cell balance by gut homeostasis plays a pivotal role in the onset and progression of PMOP. Th17 cells secrete pro-inflammatory cytokines that stimulate osteoclast activity, accelerating bone resorption, while Treg cells counteract this process through anti-inflammatory mechanisms, preserving bone mass. The gut microbiota and its metabolites can influence Th17/Treg equilibrium, thereby modulating bone metabolism. Furthermore, the integrity of the gut barrier is critical for systemic immune stability, and its disruption can lead to immune dysregulation and metabolic imbalances. Thus, targeting gut homeostasis to restore Th17/Treg balance offers a novel therapeutic avenue for the prevention and treatment of PMOP.