文献类型：期刊文献

英文题名：Using Drosophila melanogaster as a suitable platform for drug discovery from natural products in inflammatory bowel disease

作者：Xiu, Minghui[1,2,3];Wang, Yixuan[1];Yang, Dan[4];Zhang, Xueyan[1];Dai, Yuting[1];Liu, Yongqi[2,3];Lin, Xingyao[3];Li, Botong[4];He, Jianzheng[2,3,4]

第一作者：修明慧;Xiu, Minghui

通信作者：He, JZ[1];He, JZ[2];He, JZ[3]

机构：[1]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China;[3]Minist Educ, Key Lab Dunhuang Med, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China;[2]corresponding author), Minist Educ, Key Lab Dunhuang Med, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85144137123);WOS:【SCI-EXPANDED(收录号:WOS:000900134400001)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 82004228, 82104562), Gansu Lngyuan Youth Talent Innovation and Entrepreneurship Project, Talent Introduction Project in Gansu University of Chinese Medicine (No. 2018YJRC-11), The Project from the Key Laboratory of Dunhuang Medicine, Ministry of Education (Nos. DHYX19-04, DHYX19-05) (Nos. 2022CX33, 2021CX34).

语种：英文

外文关键词：inflammatory bowel disease; Drosophila melanogaster; natural products; drug discovery; molecular pathways

摘要：Inflammatory bowel disease (IBD) is a chronic and life-treating inflammatory disease that can occur in multiple parts of the human intestine and has become a worldwide problem with a continually increasing incidence. Because of its mild early symptoms, most of them will not attract people's attention and may cause more serious consequences. There is an urgent need for new therapeutics to prevent disease progression. Natural products have a variety of active ingredients, diverse biological activities, and low toxicity or side effects, which are the new options for preventing and treating the intestinal inflammatory diseases. Because of multiple genetic models, less ethical concerns, conserved signaling pathways with mammals, and low maintenance costs, the fruit fly Drosophila melanogaster has become a suitable model for studying mechanism and treatment strategy of IBD. Here, we review the advantages of fly model as screening platform in drug discovery, describe the conserved molecular pathways as therapetic targets for IBD between mammals and flies, dissect the feasibility of Drosophila model in IBD research, and summarize the natural products for IBD treatment using flies. This review comprehensively elaborates that the benefit of flies as a perfact model to evaluate the therapeutic potential of phytochemicals against IBD.