文献类型：期刊文献

英文题名：Proactive gliding-nanomachines declined tumor autophagy for enhanced tumor death

作者：Zhang, Ling[1];Du, Yongsheng[1];Gao, Rui[1];Dong, Yu[1];Zhang, Miaomiao[2];Wang, Qiaoyun[1];Tong, Fei[1];Qiao, Weiwei[3]

第一作者：Zhang, Ling

通信作者：Wang, QY[1];Tong, F[1];Qiao, WW[2]

机构：[1]Binzhou Med Univ, Sch Pharm, Dept Pharmacol, Yantai 264003, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Dept, Lanzhou, Peoples R China;[3]Binzhou Med Univ, Clin Med Coll, Yantai 264003, Peoples R China

第一机构：Binzhou Med Univ, Sch Pharm, Dept Pharmacol, Yantai 264003, Peoples R China

通信机构：[1]corresponding author), Binzhou Med Univ, Sch Pharm, Dept Pharmacol, Yantai 264003, Peoples R China;[2]corresponding author), Binzhou Med Univ, Clin Med Coll, Yantai 264003, Peoples R China.

年份：2026

卷号：30

外文期刊名：MATERIALS TODAY ADVANCES

收录：;EI(收录号：20261120286172);Scopus(收录号：2-s2.0-105032829921);WOS:【SCI-EXPANDED(收录号:WOS:001719578300001)】；

基金：This work was supported by the Shandong Provincial Natural Science Fund (Fei Tong:Grant No. ZR2022ME168) and the Binzhou Medical University Scientific Research Launch Fund Project (Fei Tong:Grant No. BY2019KYQD29) and Shandong Provincial Natural Science Fund

语种：英文

外文关键词：Active gliding-nanomachines; Autophagy; Fenton-reaction/ferroptosis amplification loop; Polyamine output; Interruption of autophagosome-lysosome fusion

摘要：Autophagy was associated with the pathophysiology of various diseases in vivo, and its own regulation was beneficial for the outcomes of specific diseases. Here, we successfully designed a biocompatible active glidingnanomachine for delivery of chloroquine (CQ)/nanodiamond (ND) and accelerated tumor cell death associated with amplifying ferroptosis and declining autophagy in vitro. Fe was covered onto one side of the surface of the L-arg@CQ/ND@HA, functioning as a controller for the dominated release of NO by sensitive ROS and Fenton-reaction from the catalyzation between Fe2+ and H2O2 in vitro. The asymmetrical NO release, which was not only the active-component to decline tumor autophagy in combination with ND/CQ, but also the propellants for the nanomachines. After implementing in tumor cell, the dynamic-sliding of nanomachines could be triggered via ROS and the proactive-gliding further strengthened diffusion of CQ/ND, leading to precise-treatment of tumors through enlarging ferroptosis accompanied by polyamine output and interruption of autophagosome lysosome fusion. The synthetized dynamic sliding-nanomachines, with ROS stimulation of movement behavior and proactive delivery of CQ/ND unlocked huge latent capacity as a potential platform for tumor treatment stemed from ferroptosis amplification loop induced polyamine output and declining autophagy in tumor cell.