文献类型：期刊文献

中文题名：基于中西医临床病证特点的强直性脊柱炎动物模型分析

英文题名：Animal Model of Ankylosing Spondylitis Based on Its Clinical Symptoms of Traditional Chinese and Western Medicine

作者：杨娟娟[1];王海东[2];王金海[3];李浩林[1];王振东[1];金芳梅[2];李伟青[2];王爱华[2];陈平[2]

第一作者：杨娟娟

机构：[1]甘肃中医药大学中医临床学院,兰州730000;[2]甘肃省中医院,兰州730050;[3]兰州大学第二医院,兰州730030

第一机构：甘肃中医药大学中医临床学院

年份：2024

卷号：26

期号：4

起止页码：944

中文期刊名：世界科学技术-中医药现代化

外文期刊名：Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD_E2023_2024】；

基金：甘肃省名中医王海东传承工作室(国中医药规财函[2021]242号):甘肃省名中医传承工作室建设项目实施方案,负责人:王海东;联合科研基金一般项目(23JRRA1535):基于IL-17诱导的DKK-1/Wnt信号轴探讨《武威汉代医简》方药五劳七损方防治强直性脊柱炎的机制研究,负责人:陈平;甘肃省中医药项目(GZKP-2022-12):督脉刺骨术配合五劳七损方治疗肾虚督寒型强直性脊柱炎的疗效评价,负责人:王爱华

语种：中文

中文关键词：强直性脊柱炎;动物模型;诊断标准;病证结合;吻合度分析

外文关键词：Ankylosing spondylitis;Animal models;Diagnostic criteria;Combination of symptoms;Anastomosis analysis

摘要：强直性脊柱炎(Ankylosing spondylitis,AS)是以炎性背痛为主要临床特点的典型脊柱关节炎,严重影响患者的身体健康和生活质量。中医药治疗强直性脊柱炎临床疗效确切,但机制不明确,现有的动物模型不能很好的应用于中医药治疗强直性脊柱炎的评价。故本文基于中西医临床诊断、病证特点、病因病机及中医证型,对现有的动物模型进行归纳总结,结果发现现有的动物模型中蛋白聚糖诱导的关节炎小鼠模型较其他模型中西医临床吻合度偏高,但缺乏相应的中医证候模型评价。其他动物模型西医临床吻合度较高,但缺乏中医证候特点。由于强直性脊柱炎是一种慢性炎症性自身免疫性疾病,致病因素复杂,现有的动物模型无法更好地模拟临床症状,故应结合强直性脊柱炎中医证候及主要外在因素(温度、湿度、刺激等),建立体现中西医病证结合的动物模型。因此,建立具有中西医临床病证特点的强直性脊柱炎动物模型是AS中医药未来的研究重点。
Ankylosing spondylitis(AS)is a typical spinal arthritis characterised by inflammatory back pain,which seriously affects the health and quality of life of patients.The clinical efficacy of Chinese medicine in the treatment of ankylosing spondylitis is clear,but the mechanism is not clear,and the existing animal models cannot be well applied to the evaluation of Chinese medicine in the treatment of ankylosing spondylitis.Therefore,this paper summarizes the existing animal models based on Chinese and Western medicine clinical diagnosis,disease characteristics,etiology and Chinese medicine evidence,and finds that among the existing animal models,the proteoglycan-induced arthritis mouse model has a higher Chinese and Western medicine clinical fit than the other models,but lacks the corresponding Chinese medicine evidence model evaluation.The other animal models had a higher Western clinical match,but lacked the characteristics of the Traditional Chinee Medicine(TCM)syndrome.As ankylosing spondylitis is a chronic inflammatory autoimmune disease with complex pathogenic factors,the existing animal models cannot better simulate the clinical symptoms.Therefore,the establishment of animal models of ankylosing spondylitis with the characteristics of Chinese and Western clinical evidence is a future research priority for AS TCM.