文献类型：期刊文献

英文题名：Study on the Effects of Acupuncture with the "Yizhi Tiaoshen" Acupoint Formula on Blood Oxygen Metabolism and Neural Function in Key Brain Regions of AD Rats

作者：Zhang, Ren-Zhen[1];Zhang, Xin[1];Zhu, Tian-Tian[1];Ye, Yu-Juan[1];Su, Ming-Li[1];Wei, Yu-Ting[1];Yan, Xing-Ke[1]

第一作者：Zhang, Ren-Zhen

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Acupuncture & Moxibust & Massage Coll, 35 Dingxi East Rd, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：14

起止页码：103

外文期刊名：DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE

收录：WOS:【ESCI(收录号:WOS:001314924200001)】；

基金：This work was supported by Gansu Provincial Key Talent Project (Gan Zu Tong Zi [2023] No. 20) ; Gansu University of Traditional Chinese Medicine Talent Introduction and Research Start up Fund Project (2019YJRC-05) ; 2024 University Teacher Innovation Fund Project (2024A-082) ; Gansu University of Traditional Chinese Medicine's 2022-2023 Talent Introduction and Research Launch Fund Project (2024YJRC-06) .

语种：英文

外文关键词：Alzheimer's disease; "Yizhi Tiaoshen" acupoint; acupuncture; functional near-infrared spectroscopy technique; brain function

摘要：Purpose: Exploring the effects of acupuncture at the "Yizhi Tiaoshen" acupoint on blood oxygen metabolism and neurological function changes in the brain regions of AD model rats. Methods: The AD model was replicated by intraperitoneal injection of D-galactose combined with bilateral hippocampal CA1 injection of Okadaic acid (OA). Thirty rats with successfully replicated model were selected through Morris water maze experiment and randomly divided into model group, donepezil hydrochloride group, and acupuncture group, with 10 rats in each group. After treatment, fNIRs were used to detect changes in Oxy Hb, Deoxy Hb, and Total Hb in the cerebral cortex of rats in each group, in order to evaluate the neurological function changes in key brain areas. Results: The escape latency of the donepezil hydrochloride group and the acupuncture group was shortened, the number of crossings through the original platform increased, and the duration of stay in the quadrant where the original platform was located was prolonged. Based on fNIRs detection, the main differential channels of blood oxygen metabolism in AD rats were identified as 2-2 and 8-7, corresponding to the prefrontal and parietal lobes, respectively. The concentrations of Oxy Hb and Total Hb were significantly increased in both treatment groups, while the concentration of Deoxy Hb was significantly decreased. Conclusion: Acupuncture with the "Yizhi Tiaoshen" acupoint formula and donepezil hydrochloride can improve the learning and memory function of AD rats, and its mechanism may be related to improving blood oxygen metabolism in the prefrontal and parietal regions and protecting neuronal function.