文献类型：会议论文

英文题名：The Preparation and Biological Toxicity Research of the New Controlled Release Carrier Nano-silica

作者：Li, Xinxin[1];Zhang, Wenjuan[1];Tong, Bobo[1];Zheng, Xiang[1];Zhao, Yali[1];Wang, Zhilong[1]

第一作者：李晓霞;李晓轩;李响响

通信作者：Li, XX[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

会议论文集：2nd International Conference on Modelling, Identification and Control (MIC)

会议日期：AUG 09-10, 2015

会议地点：Paris, FRANCE

语种：英文

外文关键词：TEOS hydrolysis method; nano silica; biocompatibility

年份：2015

摘要：The different particle sizes' nano silica spheres are synthesized by the TEOS hydrolysis method. The XRD patterns testified that the sample is single phase and its strongest peak is significantly broadened. From the photos of TEM we can see that the samples' surfaces have a good dispersion and uniform spherical morphology. The Hela cell proliferating activity is assessed by MTT assay, combined with the cell morphology and Annexin Hoechst 33342 staining are employed to determine apoptosis in Hela cells. Results shows that while the Hela cell treated with different concentrations of 200nm nano silica, cytocompatibility becomes better with the lower concentrations of nano silica. 24h cells stained photograph shows that under the concentrations of nano silica 50 mu g.ml(-1) the cell structure is normal and nucleus is complete.