文献类型：期刊文献

中文题名：肠道菌群基于脑-肠轴影响肺癌脑转移的作用机制研究进展

英文题名：Research Progress on the Mechanism of Gut Microbiota Influencing Lung Cancer Brain Metastasis via the Brain-gut Axis

作者：李丹[1];陈亮[2];吕鹏强[2];杨全石[2];杨建新[3];安德明[3];余雨[1];高国明[4]

第一作者：李丹

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属天水中西医结合医院,天水741020;[3]天水市中医医院,天水741000;[4]天水市妇幼保健院,天水741000

第一机构：甘肃中医药大学

年份：2025

卷号：28

期号：11

起止页码：849

中文期刊名：中国肺癌杂志

外文期刊名：Chinese Journal of Lung Cancer

收录：;北大核心:【北大核心2023】；

基金：甘肃省中医药科研立项课题(No.GZKG-2022-59);天水市科技支撑计划项目(No.2022-SHFZKJK-1165);天水市“成纪之星”人才项目(市组通字[2024]25号)资助。

语种：中文

中文关键词：肺肿瘤;肠道菌群;脑转移;脑-肠轴;作用机制

外文关键词：Lung neoplasms;Gut microbiota;Brain metastasis;Brain-gut axis;Mechanism of action

摘要：肺癌作为全球癌症死亡的主要原因之一,其并发症脑转移(以脑实质为主)严重影响患者的生活质量及预后。传统治疗手段,如手术、放疗及化疗,虽在临床实践中取得了一定疗效,却因毒性和患者耐受性问题而应用受限。新兴的靶向治疗与免疫治疗凭借较少的副作用展现出显著疗效,但仍然面临部分耐药及基因突变等挑战。近年来,肠道菌群与肺癌脑转移之间的关联性研究成为新热点,其作用机制可能通过脑-肠轴介导的神经内分泌-免疫多维度交互途径对肺癌脑转移进程产生影响。本文综述了肠道菌群基于脑-肠轴调控肺癌脑转移的免疫调节、内分泌代谢调节、神经递质调控等具体作用机制,及调节肠道菌群在肺癌脑转移中的治疗和传统医学研究,旨在为肺癌脑转移的防治策略提供理论支撑和临床潜在治疗靶点。
Lung cancer,one of the leading causes of cancer-related deaths worldwide,severely influences patients'quality of life and prognosis due to its complication of brain metastasis(primarily involving the brain parenchyma).While traditional treatments such as surgery,radiotherapy,and chemotherapy have demonstrated efficacy in clinical practice,their application remains limited due to toxicity and patient tolerance issues.Emerging targeted therapies and immunotherapies,which exhibit significant efficacy with fewer side effects,still face challenges including partial drug resistance and genetic mutations.In recent years,research on the association between gut microbiota and lung cancer brain metastasis has gained prominence.Its mechanism of action may influence the progression of brain metastasis through multidimensional interactions via the braingut axis,involving neuroendocrine and immune pathways.This review examines specific mechanisms by which gut microbiota modulate lung cancer brain metastasis through immune regulation,endocrine-metabolic regulation,and neurotransmitter control via the brain-gut axis,as well as therapeutic and traditional medicine research on regulating gut microbiota in lung cancer brain metastasis.It aims to provide theoretical support and identify potential clinical therapeutic targets for the prevention and treatment of lung cancer brain metastasis.