文献类型：期刊文献

中文题名：大黄化学成分、药理作用研究进展及质量标志物的预测分析

英文题名：Research progress on chemical composition and pharmacological effects of Rhei Radix et Rhizoma and predictive analysis on quality markers

作者：王玉[1];杨雪[1];夏鹏飞[1,2,3];马肖[4];杨蕊菁[1];虎峻瑞[1];樊秦[1];靳晓杰[1];武晓玉[1];彭雪晶[1,2];赵磊[1,2,3]

第一作者：王玉

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学甘肃省高校中藏药化学与质量研究省级重点实验室,甘肃兰州730000;[3]甘肃省道地药材质量标准化技术研究与推广工程实验室,甘肃兰州730000;[4]甘肃省第二人民医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2019

卷号：50

期号：19

起止页码：4821

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家自然科学基金资助项目(81660577);西北民族大学科研项目(3192016115);甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目(ddyc-2016-04);甘肃省中医药管理局科研项目(G2K-2014-77)

语种：中文

中文关键词：大黄;质量标志物;蒽醌类;蒽酮类;二苯乙烯类;苯丁酮类;质量评价

外文关键词：Rhei Radix et Rhizoma;quality marker;anthraquinones;anthracene ketones;stilbenes;phenylbutanone;quality evaluation

摘要：大黄是我国传统常用的中药材,功效独特且资源丰富,主要分布在亚温带及亚热带的高寒山区,其道地产区为我国甘肃、四川、西藏等高海拔地区。近年来,随着国内外学者对大黄全方位深入探究,其多类型的化学成分与广泛的药理作用及应用开发研究备受关注。在对大黄化学成分、传统功效、现代药理作用分析的基础上,根据质量标志物概念,从化学成分与传统药性、传统功效、临床新用途相关性、入血成分、可测成分、不同配伍中显效成分及贮藏时间影响等多方面对大黄质量标志物进行预测分析,为大黄质量评价体系的建立提供参考。
Rhei Radix et Rhizoma is a kind of traditional Chinese medicinal material in China,which has unique efficacy and rich resources.It is mainly distributed in the alpine mountains of temperate and subtropical Asia.Its genuine producing areas are Gansu Province,Qinghai Province,Sichuan Province,and Tibet Autonomous Region.In recent years,with the continuous in-depth study of Radix et Rhizoma by scholars at home and abroad,many kinds of chemical constituents,extensive pharmacological effects and application and development of Radix et Rhizoma have attracted much attention,and have broad application prospects and considerable market value.Based on the analysis of its chemical composition and traditional efficacy combined with modern pharmacological action,and according to the theory of quality marker,the quality markers of Radix et Rhizoma were predicted and analyzed from the aspects of the chemical composition and traditional medicinal properties,traditional efficacy,new clinical uses,plasma composition,measurable components,effective components in different compatibility,and the effect of storage time and so on,which provides a scientific basis for the quality evaluation of Radix et Rhizoma and establishment of its quality control system.