文献类型：期刊文献

英文题名：A case of synchronous double primary combined hepatocellular-cholangiocarcinoma complicated with gallbladder adenocarcinoma: a rare case report

作者：Wang, Xiangfei[1,2];Yang, Linru[1,2];Jian, Haiming[1,2];Gao, Xiaoru[1,3];Liu, Tianxiang[2]

第一作者：王晓凡;Wang, Xiangfei

通信作者：Liu, TX[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Peoples Hosp, Dept Surg Oncol, Lanzhou, Peoples R China;[3]Gansu Prov Peoples Hosp, Dept Radiat Oncol 1, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Surg Oncol, Lanzhou, Peoples R China.

年份：2026

卷号：16

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-105042471735);WOS:【SCI-EXPANDED(收录号:WOS:001766716100001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was funded by The Effect of Carbon Ion Irradiation on the Immune Microenvironment of Pancreatic Cancer and the New Mechanism of Immune Synergy, Grant No. 25JRRA306, and Scientific Research Initiation Fund of Talent Pool, Gansu Provincial People's Hospital (2025) (PI: Tianxiang Liu), Grant No. RC-2025-1-2.

语种：英文

外文关键词：case report; combined hepatocellular-cholangiocarcinoma; gallbladder adenocarcinoma; multiple primary cancers; synchronous double primary tumors

摘要：Multiple Primary Cancers (MPCs), especially synchronous combined hepatocellular-cholangiocarcinoma (cHCC-CCA) complicated with gallbladder adenocarcinoma, are extremely rare clinically. This case report discusses a 73-year-old female patient presenting with distending pain in the right upper abdomen, nausea, and weight loss. Contrast-enhanced abdominal computed tomography (CT) and liver-specific contrast-enhanced magnetic resonance imaging (MRI) revealed a space-occupying lesion in segment S4 of the liver (considered cholangiocarcinoma) and a nodular lesion in the gallbladder wall (considered neoplastic lesion). The patient underwent open surgery, and postoperative pathology and immunohistochemical examinations confirmed: the left hemihepatic lesion was cHCC-CCA (90% moderately differentiated cholangiocarcinoma and 10% moderately differentiated hepatocellular carcinoma), the gallbladder lesion was moderately differentiated adenocarcinoma, and no cancerous tissue involvement was found at the resection margins of the liver and gallbladder. After postoperative multidisciplinary team (MDT) discussion, the diagnosis of synchronous double primary tumors of the liver and gallbladder was confirmed. The patient recovered well after surgery, and the abdominal pain symptoms were significantly improved. This is the first reported case of synchronous double primary cHCC-CCA complicated with gallbladder adenocarcinoma at home and abroad.