文献类型：期刊文献

英文题名：Research Progress on Animal Models of Chronic Obstructive Pulmonary Disease

作者：Zhang, Yi[1,2];Liu, Zhizhong[1];Wan, Ruilin[1];Zhu, Yihe[1];Su, Miao[1];Chen, Guangshun[1];Zhao, Kunpeng[1];Pang, Qi[2];Li, Xueling[2]

第一作者：张毅;张义;张翌

通信作者：Pang, Q[1];Li, XL[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Lanzhou Gen Petrochem Hosp, Affiliated Hosp 4, Lanzhou, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou Gen Petrochem Hosp, Affiliated Hosp 4, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：21

外文期刊名：INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

收录：;Scopus(收录号：2-s2.0-105044933142);WOS:【SCI-EXPANDED(收录号:WOS:001826763100001)】；

基金：This work was supported by the National Natural Science Foundation of China Joint Fund (U23A20502),Open Fund Project of the Key Laboratory of Dunhuang Medicine, Ministry of Education (DHYX25-09),Gansu Provincial Health Industry Scientific Research Project (GSWSKY2023-69) and Gansu University of Chinese Medicine Graduate Research and Innovation Fund (2026CXCY-285).

语种：英文

外文关键词：chronic obstructive pulmonary disease; animal models; pathological mechanisms; model reference

摘要：Chronic obstructive pulmonary disease (COPD) is a long-term respiratory condition with high rates of morbidity and mortality. Its pathophysiology is complex, and currently, there are no effective clinical treatments that can fully reverse or halt the disease's progression. Animal models play a significant role in elucidating the pathogenesis of COPD, dynamic pathological processes, and evaluating potential therapeutic strategies, serving as a key to advancing in-depth research on this disease. However, existing modeling methods still face many limitations in accurately simulating the clinical symptoms, pathophysiological features, and progression of human disease, and there is a lack of standardized guidelines and industry consensus. This paper systematically reviews methods for constructing COPD animal models reported in the literature by reviewing 5,071 relevant articles from CNKI, PubMed, and Wanfang Database published in the past decade. The main models include cigarette smoke exposure, protease-induced, genetically modified, harmful substance exposure, and various combined factor models. A comprehensive review and comparison of their construction principles, procedures, pathological features, advantages, and limitations are provided. This review aims to serve as a valuable reference for COPD researchers and clinicians in the construction of animal models of COPD.