文献类型：期刊文献

中文题名：莱菔子对豚鼠体外胃窦环行肌条收缩活动的影响

英文题名：Effects of radish seeds on contractile activity of isolated antral circular muscle strips in guinea pigs

作者：李海龙[1];李梅[2];金珊[3];张小郁[3];李伟[3];郑天珍[3];瞿颂义[3]

第一作者：李海龙

机构：[1]甘肃中医学院基础部生理教研室,甘肃兰州730000;[2]上海中医药大学基础医学院生理教研室,上海200000;[3]兰州大学基础医学院生理教研室

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2008

卷号：16

期号：4

起止页码：215

中文期刊名：中国中西医结合消化杂志

外文期刊名：Chinese Journal of Integrated Traditional and Western Medicine on Digestion

收录：CSTPCD

基金：甘肃省自然科学基金项目(ZS021-A25-059-Y)

语种：中文

中文关键词：莱菔子;胃窦环行肌条;肌收缩

外文关键词：radish seeds; antral circular muscle strips; muscle contraction

摘要：[目的]观察莱菔子水煎剂对豚鼠体外胃窦环行肌条的收缩活动并探讨其作用机制。[方法]将胃窦环行肌条置于灌流肌槽内,采用累积加莱菔子和分别加阻断剂的方法,观察其对肌条收缩活动的影响。[结果]莱菔子增大胃窦环行肌条的收缩波平均振幅及其收缩频率,并呈一定剂量依赖关系,M3胆碱能受体拮抗剂4-DAMP可部分阻断其振幅的增大。[结论]莱菔子水煎剂增大豚鼠胃窦环行肌条收缩波平均振幅的作用可能部分经由兴奋胆碱能M3受体而不是胆碱能M2受体。
[Objective]To study the effects of water extracts of radish seeds on contractile activity of isolated antral circular muscle strips and its possible mechanism in guinea pigs. [Methods]Antral circular muscle strips were suspended in tissue chambers and the contractile activity were recorded. Radish seeds were added cumulatively and antagonists were added separately. [Results] Administration of radish seeds dose dependently increased mean contractile amplitude and frequency of antral circular strips. Cholinergic Ma antagonist 4-DAMP decreased its mean contractile amplitude partly. [Conclusion ]The results suggest that radish seeds dose dependently increased mean contractile amplitude of antral circular strips of guinea pigs. The exciting action of radish seeds is partly mediated via cholinergic M3 receptor, but not cholinergic M2 receptor.