文献类型：期刊文献

英文题名：Biao and Ben Acupoints Combination Regulates Mitochondrial Function Through Purinergic P2X7 Receptor in Rats with Myocardial Ischemia

作者：Yu, Qiushuang[1];Li, Shaokun[1];Chang, Yanna[1];Yan, Dongling[2];Feng, Xiuling[1]

第一作者：于秋爽

通信作者：Feng, XL[1]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Dept Anesthesia & Surg, Lanzhou 730020, Peoples R China;[2]Lanzhou Maternal & Child Hlth Hosp, Dept Anesthesia & Surg, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Anesthesia & Surg, Lanzhou 730020, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2023

卷号：19

期号：4

起止页码：648

外文期刊名：JOURNAL OF BIOMEDICAL NANOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001024207700001)】；

基金：Acknowledgments: This study was sup p orted by Natu-ral Science Foundation of Gansu Province (21JR7RA578) .

语种：英文

外文关键词：Myocardial Ischemia; Biao and Ben Acupoints; Mitochondria

摘要：We aimed to investigate the possible mechanisms of electroacupuncture at the Biao and Ben acupoints in improving myocardial ischemia-induced mitochondrial dysfunction. The study examined mitochondrial structure, ATP production, cytosolic calcium accumulation, P2X7 receptor, and mitochondrial-associated oxidative stress factors in rats with a myocardial ischemia model. Eighty-four male and female SD rats were randomly divided into seven groups: Control, Sham, Model, High-dose/Low-dose ZnCl2, electroacupuncture at the Neiguan point, and the Combination of Biao and Ben acupoints. The electroacupuncture groups, including the Neiguan point and Biao and Ben acupoints group, were treated with acupuncture for 10 minutes per day for 21 days. The combination of Biao and Ben acupoints decreased the damage to the mitochondrial structure caused by myocardial ischemia, restored ATP production, and inhibited Ca2+ accumulation. Furthermore, electroacupuncture at Biao and Ben inhibited calcium accumulation and restored P2X7 receptor expression P: 2038 10920 On: Fri 07 Jul 2023 10:33:19 levels. The protective effect of the combination of Biao and Ben acupoints on mitochondrial function is that they restore Copyright: American Scientific Publishers P2X7 receptor expression, which regulates mitochondrial metabolism. Delivered by Ingen