文献类型：期刊文献

英文题名：Regulation and mechanism of Astragalus polysaccharide on ameliorating aging in Drosophila melanogaster

作者：Li, Xu[1,5]; Yang, Shipei[2,3]; Wang, Shuwei[1]; Shi, Yan[2,3]; Dai, Yuting[1]; Zhang, Xueyan[1]; Liu, Yongqi[2,4]; Guo, Yaqiong[6]; He, Jianzheng[2,3,4]; Xiu, Minghui[1,4]

第一作者：Li, Xu;许丽

机构：[1] College of Public Health, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [2] Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [3] College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [4] Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [5] Institute of Infection, the First Hospital of Lanzhou University, Lanzhou, 730000, China; [6] Second Provincial People's Hospital of Gansu, Lanzhou, 730000, China

第一机构：甘肃中医药大学

通信机构：[2]Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, 730000, China;[1]College of Public Health, Gansu University of Chinese Medicine, Lanzhou, 730000, China|[10735]甘肃中医药大学;

年份：2023

卷号：234

外文期刊名：International Journal of Biological Macromolecules

收录：EI(收录号：20240815594772);Scopus(收录号：2-s2.0-85148761468)

语种：英文

外文关键词：Neurodegenerative diseases - Signaling - Sleep research

摘要：Astragalus polysaccharide (APS) is a notable bioactive component of Astragalus membranaceus and has been extensively investigated for its pharmacological activities, including antioxidant, neuroprotection, and anticancer effects. However, the beneficial effects and mechanisms of APS on anti-aging diseases remain largely unknown. Here, we utilized the classic model organism Drosophila melanogaster to investigate the beneficial effects and mechanism of APS on aging-related intestinal homeostasis imbalance, sleeping disorders, and neurodegenerative diseases. The results showed that administration of APS significantly attenuated age-associated disruption of the intestinal barrier, loss of gastrointestinal acid-base balance, reduction in intestinal length, overproliferation of the intestinal stem cells (ISCs), and sleeping disorders upon aging. Furthermore, APS supplementation delayed the onset of Alzheimer's phenotypes in Aβ42-induced Alzheimer's disease (AD) flies, including the extension of lifespan and the increase in motility, but without rescuing neurobehavioral deficits in the AD model of taupathy and Parkinson's disease (PD) model of Pink1 mutation. In addition, transcriptomics was used to dissect updated mechanisms of APS on anti-aging, such as JAK-STAT signaling, Toll signaling, and IMD signaling pathways. Taken together, these studies indicate that APS plays a beneficial role in modulating aging-related diseases, thereby as a potential natural drug to delay aging. ? 2023 Elsevier B.V.